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一名糖尿病控制不佳患者并发累及胃肠道的毛霉菌病和隐球菌病

Mucormycosis and Cryptococcosis with Gastrointestinal Involvement in a Patient with Poorly Managed Diabetes.

作者信息

Aldahash Bader A, Alnemer Mohammed A, Alsaad Khaled O, Alsohaibani Fahad I

机构信息

Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Department of Medicine, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

出版信息

Saudi J Med Med Sci. 2023 Jan-Mar;11(1):89-92. doi: 10.4103/sjmms.sjmms_201_22. Epub 2023 Jan 4.

DOI:10.4103/sjmms.sjmms_201_22
PMID:36908999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9997857/
Abstract

Mucormycosis and cryptococcosis are invasive fungal infections that mostly infect immunocompromised patients and are associated with high mortality rates. Here, we report a case of a 54-year-old male with poorly controlled diabetes mellitus who was initially admitted with a complaint of right frontal headache and vomiting for 5 days. The patient was found to have paranasal sinuses mucormycosis, and later developed gastrointestinal cryptococcosis. A multidisciplinary approach and early management are important to avoid any delay in managing these life-threatening infections. To the best of the authors' knowledge, this is the first case reporting concurrent invasive fungal infections in a patient.

摘要

毛霉病和隐球菌病是侵袭性真菌感染，主要感染免疫功能低下的患者，且死亡率很高。在此，我们报告一例54岁男性患者，其糖尿病控制不佳，最初因右侧额部头痛和呕吐5天入院。该患者被诊断为鼻旁窦毛霉病，随后又患上胃肠道隐球菌病。多学科方法和早期管理对于避免延误治疗这些危及生命的感染至关重要。据作者所知，这是首例报告患者同时发生侵袭性真菌感染的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/4090ee6c701b/SJMMS-11-89-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/cdcd6da3efa4/SJMMS-11-89-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/8fd1414dc8e8/SJMMS-11-89-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/05c3d1f3c807/SJMMS-11-89-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/4090ee6c701b/SJMMS-11-89-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/cdcd6da3efa4/SJMMS-11-89-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/8fd1414dc8e8/SJMMS-11-89-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/05c3d1f3c807/SJMMS-11-89-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d900/9997857/4090ee6c701b/SJMMS-11-89-g004.jpg

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本文引用的文献

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Lancet Microbe. 2022 Jul;3(7):e543-e552. doi: 10.1016/S2666-5247(21)00237-8. Epub 2022 Jan 25.
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Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India.COVID-19 相关毛霉菌病：全球及印度病例报告的系统综述。
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Successful treatment of gastrointestinal mucormycosis in an adult with acute leukemia: case report and literature review.成人急性白血病合并胃肠道毛霉菌病的成功治疗：病例报告及文献综述
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Invasive fungal disease of the sinus and orbit: a comparison between mucormycosis and Aspergillus.鼻窦和眼眶的侵袭性真菌病：毛霉病与曲霉病的比较
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