Guerrero Saldivia Sara Elena, Unnikrishnan Sumedha, Chavarria Yeny Y, Akindele Adebisi O, Jalkh Ana P, Eastmond Aziza K, Shetty Chaitra, Rizvi Syed Muhammad Hannan Ali, Sharaf Joudi, Williams Kerry-Ann D, Tariq Maha, Acharekar Maitri V, Balani Prachi
Ophthalmology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, Government Medical College, Kozhikode, Thrissur, IND.
Cureus. 2023 Feb 7;15(2):e34735. doi: 10.7759/cureus.34735. eCollection 2023 Feb.
Zika virus infection (ZIKV) was one of the most catastrophic epidemics. ZIKV in nonpregnant women is mild and sometimes asymptomatic. However, infection during pregnancy leads to congenital malformations in the fetus, while maternal signs of infection are preceded by a rash. The maternal-fetal infection begins with a rash that occurs early during pregnancy. The most severe pathologies were related to the first trimester of gestation, including microcephaly, musculoskeletal, genitourinary, craniofacial, ocular, and pulmonary manifestations. The prognosis may not be encouraging. Herd immunity increases CD8 (cytotoxic T-lymphocytes) earlier and decreases in the resolution phase. However, CD4 (T-helper cells) remains higher after infection. Recent ongoing vaccine development shows good immunity, control of the vector (Aedes mosquitoes), and treatment. ZIKV, anomalies, mortality, herd immunity, and vaccine were our main keywords. This systematic review demonstrates the teratogenesis of ZIKV in children, congenital anomalies, mortality, and a view of the future and behavior of ZIKV.
寨卡病毒感染（ZIKV）是最具灾难性的流行病之一。寨卡病毒在非孕妇中症状较轻，有时无症状。然而，孕期感染会导致胎儿出现先天性畸形，而孕妇感染的体征之前会出现皮疹。母婴感染始于孕期早期出现的皮疹。最严重的病理情况与妊娠早期有关，包括小头畸形、肌肉骨骼、泌尿生殖、颅面、眼部和肺部表现。预后可能并不乐观。群体免疫会使CD8（细胞毒性T淋巴细胞）更早增加，并在消退期减少。然而，感染后CD4（辅助性T细胞）仍会保持较高水平。近期正在进行的疫苗研发显示出良好的免疫效果、对病媒（伊蚊）的控制及治疗效果。寨卡病毒、异常情况、死亡率、群体免疫和疫苗是我们的主要关键词。本系统评价展示了寨卡病毒对儿童的致畸作用、先天性异常、死亡率以及对寨卡病毒未来情况和表现的展望。
