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先天性寨卡综合征相关小头畸形的病死率及相关因素：巴西全国回顾性研究†。

Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †.

机构信息

Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil.

Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil.

出版信息

Viruses. 2020 Oct 29;12(11):1228. doi: 10.3390/v12111228.

DOI:10.3390/v12111228
PMID:33138282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7692842/
Abstract

BACKGROUND

The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child's health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child-maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015-2017.

METHODS

Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied.

RESULTS

The microcephaly/CZS case fatality rate was 10% (95% CI 9.2-10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15; 95% CI 1.63-2.83), and very low birth weight (OR = 3.77; 95% CI 2.20-6.46); late preterm births (OR = 1.65; 95% CI 1.21-2.23), Apgar < 7 at 1st (OR = 5.98; 95% CI 4.46-8.02) and 5th minutes (OR = 4.13; 95% CI 2.78-6.13), among others.

CONCLUSIONS

A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.

摘要

背景

小头畸形/先天性寨卡综合征（microcephaly/CZS）的临床表现对儿童健康造成严重后果，增加了儿童发病率和死亡率的脆弱性。本研究分析了 2015-2017 年巴西小头畸形/CZS 病例和死亡相关的病死率和母婴特征。

方法

通过三个信息系统的链接进行基于人群的研究。我们根据儿童和产妇特征以及死因，估计小头畸形/CZS 病例、死亡和病死率的频率。应用多变量逻辑回归模型。

结果

小头畸形/CZS 的病死率为 10%（95%CI 9.2-10.7）。与小头畸形/CZS 相关的死亡与中度（OR=2.15；95%CI 1.63-2.83）和极低出生体重（OR=3.77；95%CI 2.20-6.46）；晚期早产儿（OR=1.65；95%CI 1.21-2.23），1 分钟时 Apgar<7（OR=5.98；95%CI 4.46-8.02）和 5 分钟时 Apgar<7（OR=4.13；95%CI 2.78-6.13），等等。

结论

观察到小头畸形/CZS 的病死率较高，与该综合征相关的死亡的重要因素。这些结果可以提醒卫生保健团队注意这些问题，并提高对可能与更差结果相关的因素的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb1/7692842/39891c421d14/viruses-12-01228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb1/7692842/39891c421d14/viruses-12-01228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb1/7692842/39891c421d14/viruses-12-01228-g001.jpg

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