The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, Guiyang 550000, China.
Biomed Res Int. 2020 Mar 2;2020:8780253. doi: 10.1155/2020/8780253. eCollection 2020.
The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still controversial. Therefore, we aimed to further study the association between these two parameters.
The present study is an observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in Guangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the outcome variable were serum progesterone measured at baseline and early pregnancy outcome, respectively. Covariates involved in this study included patients' basic demographics, obstetric history, and clinical information.
A negative association and a saturation effect were detected between serum progesterone and the first trimester pregnancy outcome. When progesterone <90.62 nmol/L, an increase in 1 nmol/L of serum progesterone was associated with 3% decrease of the risk of miscarriage (OR: 0.97, 95% CI: 0.95-0.98).
There was a greater risk of abortion when the serum progesterone level was less than 90.62 nmol/L. Our findings can better assist the clinician in understanding patients' conditions and making medical decisions.
血清孕激素与先兆流产的早期妊娠结局之间的关系仍存在争议。因此，我们旨在进一步研究这两个参数之间的关系。
本研究是一项观察性回顾性队列研究。本研究共纳入了 2011 年 8 月 17 日至 2018 年 10 月 30 日期间来自中国广东某医院的 726 例有先兆流产的患者。暴露变量和结局变量分别为基线时测量的血清孕激素和早期妊娠结局。本研究涉及的协变量包括患者的基本人口统计学、产科史和临床信息。
血清孕激素与早期妊娠结局之间存在负相关和饱和效应。当孕激素<90.62 nmol/L 时，血清孕激素增加 1 nmol/L 与流产风险降低 3%相关（OR：0.97，95%CI：0.95-0.98）。
当血清孕激素水平<90.62 nmol/L 时，流产的风险更大。我们的发现可以帮助临床医生更好地了解患者的病情并做出医疗决策。
