Zhang Yan, Wang Wei, Chen Tingting
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Oncol Lett. 2023 Feb 22;25(4):141. doi: 10.3892/ol.2023.13727. eCollection 2023 Apr.
Lymphoid neoplasm with 18q21.3/BCL2 and 8q24/MYC translocation to immunoglobulin genes as dual-hit lymphoma in female bilateral ovaries is rare and has a poor clinical outcome. The present study reported on the case of a 33-year-old female, who was admitted to the hospital due to lower abdominal distension aggravated during defecation but with no obvious inducement. The B-ultrasound revealed bilateral adnexal solid masses and the pathological examination indicated advanced B-cell lymphoma (HGBL) with MYC and BCL2 gene rearrangement. The patient then received R-CHOP treatment, but the effects were poor. Rare extranodal HGBL presentations with MYC and BCL2 rearrangement should be considered in the differential diagnosis of masses at unusual sites, such as the adnexa. Due to their aggressive nature, early and prompt recognition of these lymphomas is essential for appropriately administering therapies.
具有18q21.3/BCL2和8q24/MYC易位至免疫球蛋白基因的淋巴样肿瘤作为双打击淋巴瘤发生于女性双侧卵巢十分罕见，且临床预后较差。本研究报告了一例33岁女性病例，该患者因排便时腹胀加剧入院，无明显诱因。B超显示双侧附件实性肿块，病理检查提示为具有MYC和BCL2基因重排的高级别B细胞淋巴瘤（HGBL）。该患者随后接受了R-CHOP治疗，但效果不佳。在鉴别诊断不寻常部位（如附件）的肿块时，应考虑罕见的伴有MYC和BCL2重排的结外HGBL表现。由于其侵袭性，早期和及时识别这些淋巴瘤对于合理进行治疗至关重要。
