Santoni R, Bucciolini M, Cionini L, Ciraolo L, Renzi R
Radiation Therapy Unit, University of Florence, Italy.
Clin Radiol. 1987 Nov;38(6):569-73. doi: 10.1016/s0009-9260(87)80325-2.
Pelvic Magnetic Resonance Imaging (MRI) was performed in eight healthy women and in eight patients with carcinoma of the cervix, using a 0.5 T superconductive magnet, to evaluate relaxation times of the normal uterine cervix and carcinomas. Spin-lattice (T1) and spin-spin (T2) relaxation times for skeletal muscle, adipose tissue and bone marrow of the epiphysis of the femur were also measured in all cases. In the group of patients with carcinoma of the cervix MRI was performed before, during and after radiation therapy. The mean T1 and T2 values for the normal uterine cervix and cervical carcinoma were evaluated. Mean spin-lattice time for carcinomas were confirmed to be higher than the mean calculated value for the normal cervix, while no significant variation was observed with respect to spin-spin time. A high individual T1 and T2 variability was noted not only in the group of patients affected by cervical carcinoma, but among the healthy subjects too. After radiation therapy a mean T1 time reduction of approximately 20% was found in cervical carcinomas compared with pretreatment measurements, whereas no difference was evident for T2 time. These preliminary results confirm that reduction in spin-lattice time is demonstrated in tumours submitted to radiation therapy. More detailed biological information, such as percentages of vital and necrotic cells, tissue water content and cellular kinetics are probably necessary for a clearer understanding of this phenomenon even in an apparently homogeneous group of patients.
对8名健康女性和8名宫颈癌患者进行了盆腔磁共振成像（MRI）检查，使用0.5T超导磁体，以评估正常子宫颈和癌组织的弛豫时间。所有病例均测量了股骨骨骺的骨骼肌、脂肪组织和骨髓的自旋晶格（T1）和自旋-自旋（T2）弛豫时间。对宫颈癌患者组在放疗前、放疗期间和放疗后进行了MRI检查。评估了正常子宫颈和宫颈癌的平均T1和T2值。证实癌组织的平均自旋晶格时间高于正常子宫颈的平均计算值，而自旋-自旋时间未观察到显著变化。不仅在宫颈癌患者组中，而且在健康受试者中也注意到个体T1和T2的高度变异性。放疗后，与治疗前测量值相比，宫颈癌的平均T1时间减少了约20%，而T2时间没有明显差异。这些初步结果证实，接受放疗的肿瘤显示出自旋晶格时间缩短。即使在一组看似同质的患者中，可能也需要更详细的生物学信息，如活细胞和坏死细胞的百分比、组织含水量和细胞动力学，才能更清楚地理解这一现象。
