Santoni R, Bucciolini M, Chiostrini C, Cionini L, Renzi R
Radiation Therapy Unit, University of Florence, Firenze, Italy.
Br J Radiol. 1991 Jun;64(762):498-504. doi: 10.1259/0007-1285-64-762-498.
T1 and T2 relaxation times were calculated, before radiation therapy, in 30 patients with cervical carcinoma. Eight healthy young women were submitted to magnetic resonance imaging (MRI) to determine T1 and T2 times of the normal cervix. Magnetic resonance imaging was repeated, in 22 patients, during radiation therapy and at follow-up. During treatment and follow-up, patients with complete tumour response showed a significant T1 reduction compared with the pre-treatment values. With persistence of palpable or visible tumour, T1 times showed a small decrease during therapy, and a marked increase at subsequent examinations. The results suggest that the modifications of T1 times, during radiation therapy and follow-up, could be considered as a useful discriminant between patients with differing tumour response.
在30例宫颈癌患者放疗前计算其T1和T2弛豫时间。对8名健康年轻女性进行磁共振成像（MRI）以确定正常宫颈的T1和T2时间。对22例患者在放疗期间及随访时重复进行磁共振成像。在治疗和随访期间，肿瘤完全缓解的患者与治疗前相比T1显著降低。若仍可触及或可见肿瘤，T1时间在治疗期间略有下降，而在随后的检查中显著增加。结果表明，放疗期间及随访时T1时间的改变可作为区分不同肿瘤反应患者的有用指标。
