Onoja Remigius Ibe, Olumuyiwa Shoyinka Shodeinde Vincent, Omeke Jacinta Ngozi, Emejuo Nnenna Tochi, Ugwoke Stella Nkemdilim
Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Vet Res Forum. 2023;14(2):59-64. doi: 10.30466/vrf.2021.537224.3219. Epub 2023 Feb 15.
Benign prostatic hyperplasia (BPH) is an age-related disease in dogs and man leading to prostate enlargement which impinges on the urethra causing urinary outflow obstruction. Due to the side effects of surgery and chemotherapy used for the treatment of this disease, attention is now focused on phytotherapeutics for its management. Thus, we investigated the inhibitory effect of hydro-methanol extract of (HMECO) on testosterone propionate (TP)-induced BPH rat model. A total of forty-two 10-12 weeks old male Sprague-Dawley outbred albino rats () weighing 200 - 250 g were randomly divided into six equal groups of seven rats each based on body weight as follows: A) Control group given phosphate-buffered saline orally and corn oil subcutaneously (SC) once daily, B) TP at a dose of 3.00 mg kg SC once daily, C) TP at a dose of 3.00 mg kg SC and finasteride at a dose of 10.00 mg kg orally once daily, D) TP at a dose of 3.00 mg kg SC plus 200 mg kg HMECO orally once daily, E) TP at a dose of 3.00 mg kg SC plus 400 mg kg HMECO orally once daily and F) TP at a dose of 3.00 mg kg SC plus 800 mg kg HMECO orally once daily for 28 days. Results showed that HMECO significantly reduced prostate weight, prostatic index; serum levels of testosterone and prostatic epithelial thickness and increased luminal diameter in BPH induced rats. Thus, the results of this study suggest that is a potential pharmacological candidate for the management of BPH.
良性前列腺增生（BPH）是一种与年龄相关的疾病，在犬类和人类中都会导致前列腺肿大，进而压迫尿道，造成尿路梗阻。由于用于治疗该疾病的手术和化疗存在副作用，目前人们将注意力集中在植物疗法上。因此，我们研究了[具体植物名称]水甲醇提取物（HMECO）对丙酸睾酮（TP）诱导的BPH大鼠模型的抑制作用。总共42只10 - 12周龄、体重200 - 250克的雄性斯普拉格-道利远交白化大鼠，根据体重随机分为六组，每组七只，具体分组如下：A）对照组，每天口服磷酸盐缓冲盐水并皮下注射（SC）玉米油一次；B）TP组，剂量为3.00毫克/千克，每天皮下注射一次；C）TP + 非那雄胺组，TP剂量为3.00毫克/千克，每天皮下注射一次，非那雄胺剂量为10.00毫克/千克，每天口服一次；D）TP + 200毫克/千克HMECO组，TP剂量为3.00毫克/千克，每天皮下注射一次，HMECO剂量为200毫克/千克，每天口服一次；E）TP + 400毫克/千克HMECO组，TP剂量为3.00毫克/千克，每天皮下注射一次，HMECO剂量为400毫克/千克，每天口服一次；F）TP + 800毫克/千克HMECO组，TP剂量为3.00毫克/千克，每天皮下注射一次，HMECO剂量为800毫克/千克，每天口服一次，持续28天。结果表明，HMECO显著降低了BPH诱导大鼠的前列腺重量、前列腺指数、血清睾酮水平和前列腺上皮厚度，并增加了管腔直径。因此，本研究结果表明，[具体植物名称]是治疗BPH的潜在药理候选物。
