Krzych-Fałta Edyta, Wojas Oksana, Namysłowski Andrzej, Samoliński Bolesław, Białek Sławomir, Furmańczyk Konrad
Department of Basic Nursing, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland.
Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
Postepy Dermatol Alergol. 2023 Feb;40(1):87-92. doi: 10.5114/ada.2022.124099. Epub 2023 Jan 16.
The nasal allergen provocation test plays an important role in differential diagnostics of rhinitis. Due to its informative potential, the test is also becoming increasingly used in other areas of diagnostics, including the diagnostics of food allergies.
To assess the reactivity of nasal mucosa to the cow's milk protein allergens (as being widely used in powdered form in the food industry).
The study material consisted of a group of 31 healthy subjects not sensitized to environmental allergens including cow's milk protein allergens. The study method involved an incremental nasal provocation test with cow's milk protein evaluated using the visual analog scale and acoustic rhinometry.
A total of 29 out of 31 volunteers presented with a significant decrease in nasal patency (control solution: 1.112 ±0.161 vs. local allergen application 1.005 ±0.157; < 0.004) as measured by acoustic rhinometry following the allergen dose of 12.5 μg. Slight changes in complaints were observed using the visual analog scale. Exposure to the widespread food allergens (including powdered cow's milk allergens) presents a potential risk of positive response in non-sensitized individuals.
Further studies on dose standardization are necessary in the study area.
鼻过敏原激发试验在鼻炎的鉴别诊断中起着重要作用。由于其信息价值，该试验在包括食物过敏诊断在内的其他诊断领域也越来越多地被使用。
评估鼻黏膜对牛奶蛋白过敏原（在食品工业中广泛以粉末形式使用）的反应性。
研究材料包括一组31名对环境过敏原（包括牛奶蛋白过敏原）未致敏的健康受试者。研究方法包括使用视觉模拟量表和鼻声反射测量法对牛奶蛋白进行递增鼻激发试验。
在12.5μg过敏原剂量后，通过鼻声反射测量法测量，31名志愿者中有29名鼻通畅度显著下降（对照溶液：1.112±0.161 vs. 局部应用过敏原：1.005±0.157；<0.004）。使用视觉模拟量表观察到主诉有轻微变化。接触广泛存在的食物过敏原（包括奶粉形式的牛奶过敏原）在未致敏个体中存在阳性反应的潜在风险。
该研究领域有必要进一步开展剂量标准化研究。
