Zheng Koulong, Bai Jie, Xu Louyuan, Chen Liang
Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong, China.
J Thorac Dis. 2023 Feb 28;15(2):627-634. doi: 10.21037/jtd-23-124.
This study sought to investigate the expression of soluble semaphorin 4D (sSema4D) in acute ST-segment elevation myocardial infarction (STEMI) and to explore its value in evaluating the inflammatory status of acute myocardial infarction (AMI).
From October 2020 to June 2021, 100 patients with STEMI diagnosed at the Department of Cardiology of our hospital were selected as the STEMI group, 83 patients with unstable angina (UA) were selected as the UA group, and 78 patients with negative coronary angiography (CAG) were selected as the control group. The baseline data of the 3 groups of patients were recorded, the sSema4D levels were determined, the expression of sSema4D levels in AMI was analyzed, and the value of sSema4D levels in reflecting inflammatory state of AMI was explored.
Compared with UA group and control group, the expression of sSema4D in peripheral blood of STEMI group was significantly increased (P<0.001), which could better reflect the inflammatory status of patients with STEMI than traditional inflammatory indicators [hypersensitive c-reactive protein (hs-CRP)] (P<0.05). The receiver operating characteristic (ROC) curve showed that sSema4D (AUC =0.780, cut-off =19.62, 95% CI: 0.629, 0.837, P<0.001) was more specific than hs-CRP (AUC =0.697, cut-off =3.39, 95% CI: 0.629, 0.765, P<0.001) in reflecting the inflammatory status of STEMI patients.
sSema4D levels have certain value in reflecting the inflammatory state of STEMI.
本研究旨在探讨可溶性信号素4D（sSema4D）在急性ST段抬高型心肌梗死（STEMI）中的表达情况，并探索其在评估急性心肌梗死（AMI）炎症状态中的价值。
选取2020年10月至2021年6月在我院心内科确诊的100例STEMI患者作为STEMI组，选取83例不稳定型心绞痛（UA）患者作为UA组，选取78例冠状动脉造影（CAG）阴性患者作为对照组。记录3组患者的基线资料，测定sSema4D水平，分析AMI中sSema4D水平的表达情况，并探索sSema4D水平在反映AMI炎症状态中的价值。
与UA组和对照组相比，STEMI组外周血中sSema4D的表达显著升高（P<0.001），与传统炎症指标[超敏C反应蛋白（hs-CRP）]相比，其能更好地反映STEMI患者的炎症状态（P<0.05）。受试者工作特征（ROC）曲线显示，在反映STEMI患者炎症状态方面，sSema4D（AUC =0.780，临界值 =19.62，95%CI：0.629，0.837，P<0.001）比hs-CRP（AUC =0.697，临界值 =3.39，95%CI：0.629，0.765，P<0.001）更具特异性。
sSema4D水平在反映STEMI炎症状态方面具有一定价值。
