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一种用于靶向脊髓刺激的新型电流转向方法。

A novel current steering method for targeted spinal cord stimulation.

作者信息

Mishra Lakshmi Narayan, Kulkarni Gaurav, Gadgil Mandar

机构信息

Nalu Medical Inc., Carlsbad, CA, United States.

Oneirix Engineering Laboratories Pvt. Ltd., Pune, MH, India.

出版信息

Front Pain Res (Lausanne). 2023 Feb 23;4:1028368. doi: 10.3389/fpain.2023.1028368. eCollection 2023.

Abstract

Spinal Cord Stimulation (SCS) with leads embedded in the epidural space has become a recognized and effective clinical therapy for chronic pain relief. Leads with multiple electrodes placed close to the spinal cord allow targeted stimulation. This paper presents a novel current steering method to achieve targeted spinal cord stimulation by determining the optimal current sourced through a set of electrodes to maximize current density in a specified region of the spinal cord. The method provides a flexibility for personalized pain relief therapy, while minimizing stimulation in unwanted regions. The paper proposes a new optimization problem to achieve current steering. The optimization problem uses a solution of the Poisson equation evaluated using Finite Element Analysis (FEA) over a geometric model of the spinal cord and the embedded leads. The solution to the optimization problem determines the optimal current sourced through a set of electrodes to achieve a targeted stimulation.

摘要

将电极植入硬膜外腔的脊髓刺激(SCS)已成为一种公认的、有效的缓解慢性疼痛的临床疗法。带有多个电极的导联放置在靠近脊髓的位置,可实现靶向刺激。本文提出了一种新颖的电流控制方法,通过确定通过一组电极提供的最佳电流,以在脊髓的指定区域最大化电流密度,从而实现靶向脊髓刺激。该方法为个性化疼痛缓解治疗提供了灵活性,同时将对不需要区域的刺激降至最低。本文提出了一个新的优化问题来实现电流控制。该优化问题使用通过有限元分析(FEA)在脊髓和植入导联的几何模型上评估的泊松方程的解。优化问题的解确定通过一组电极提供的最佳电流,以实现靶向刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3564/9996238/677f0625aa5b/fpain-04-1028368-g001.jpg

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