Mishra Lakshmi Narayan, Kulkarni Gaurav, Gadgil Mandar
Nalu Medical Inc., Carlsbad, CA, United States.
Oneirix Engineering Laboratories Pvt. Ltd., Pune, MH, India.
Front Pain Res (Lausanne). 2023 Feb 23;4:1028368. doi: 10.3389/fpain.2023.1028368. eCollection 2023.
Spinal Cord Stimulation (SCS) with leads embedded in the epidural space has become a recognized and effective clinical therapy for chronic pain relief. Leads with multiple electrodes placed close to the spinal cord allow targeted stimulation. This paper presents a novel current steering method to achieve targeted spinal cord stimulation by determining the optimal current sourced through a set of electrodes to maximize current density in a specified region of the spinal cord. The method provides a flexibility for personalized pain relief therapy, while minimizing stimulation in unwanted regions. The paper proposes a new optimization problem to achieve current steering. The optimization problem uses a solution of the Poisson equation evaluated using Finite Element Analysis (FEA) over a geometric model of the spinal cord and the embedded leads. The solution to the optimization problem determines the optimal current sourced through a set of electrodes to achieve a targeted stimulation.
将电极植入硬膜外腔的脊髓刺激（SCS）已成为一种公认的、有效的缓解慢性疼痛的临床疗法。带有多个电极的导联放置在靠近脊髓的位置，可实现靶向刺激。本文提出了一种新颖的电流控制方法，通过确定通过一组电极提供的最佳电流，以在脊髓的指定区域最大化电流密度，从而实现靶向脊髓刺激。该方法为个性化疼痛缓解治疗提供了灵活性，同时将对不需要区域的刺激降至最低。本文提出了一个新的优化问题来实现电流控制。该优化问题使用通过有限元分析（FEA）在脊髓和植入导联的几何模型上评估的泊松方程的解。优化问题的解确定通过一组电极提供的最佳电流，以实现靶向刺激。
