Department of Echocardiograhy, Tangshan Worker Hospital, Tangshan 063000, China.
Afr Health Sci. 2022 Sep;22(3):329-335. doi: 10.4314/ahs.v22i3.35.
To investigate the effect of atrial septal aneurysm (ASA) and patent foramen ovale (PFO) on cryptogenic ischemic stroke in young and middle-aged patients.
A case-control study was conducted to select 96 young and middle-aged patients with cryptogenic ischemic stroke in the Department of Neurology of our hospital from January 2015 to January 2020 (observation group). A total of 192 patients with non-ischemic stroke were selected as the control group. The clinicadata and transthoracic echocardiography (cTTE) results were compared between the two groups.
The ASA depth and tumor wall thickness in the observation group were 15.50 (12.40, 19.80) mm and 3.90 (2.80,4.50) mm, respectively, which were significantly higher than those in the control group (P < 0.05). Logistic regression analysis showed that PFO, and PFO combined with ASA were the influencing factors of cryptogenic ischemic stroke in middle-aged and young people OR = 1.923 and 1.384, P < 0.05).
Atrial septal aneurysm combined with PFO and PFO are independent influencing factors factor for the occurrence of cryptogenic ischemic stroke in young and middle-aged people, which is worthy of further study.
探讨房间隔瘤（ASA）和卵圆孔未闭（PFO）对中青年隐源性缺血性卒中的影响。
采用病例对照研究，选取 2015 年 1 月至 2020 年 1 月我院神经内科收治的中青年隐源性缺血性卒中患者 96 例为观察组。选取同期非缺血性卒中患者 192 例为对照组。比较两组临床资料和经胸超声心动图（cTTE）结果。
观察组的 ASA 深度和瘤壁厚度分别为 15.50（12.40，19.80）mm 和 3.90（2.80，4.50）mm，均明显高于对照组（P<0.05）。Logistic 回归分析显示，PFO 和 PFO 合并 ASA 是中青年隐源性缺血性卒中的影响因素，OR 值分别为 1.923 和 1.384，P<0.05）。
房间隔瘤合并 PFO 和单纯 PFO 是中青年隐源性缺血性卒中发生的独立影响因素，值得进一步研究。
