伊朗西北部嗜酸性粒细胞儿童弓蛔虫病血清流行率及相关危险因素调查。
A survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic children of Northwest Iran.
机构信息
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
Afr Health Sci. 2022 Sep;22(3):617-625. doi: 10.4314/ahs.v22i3.66.
BACKGROUND
Toxocariasis is a serious zoonotic helminthic disease caused by the nematodes; species.
AIM
A cross-sectional study was conducted to determine the seroprevalence of toxocariasis and related risk factors in eosinophilic children referred to the pediatrics hospital of Qazvin province northwest Iran during 2019-2020.
METHODS
A total of 200 blood samples were collected from eosinophilic children referred to the Qods Pediatrics Hospital. Demographic data, clinical symptoms, and dogs- and soil-contact history were collected. The presence of anti- IgG antibody was evaluated by IgG ELISA kit.
RESULTS
Anti- IgG antibodies were detected in 14 (7%) of the total eosinophilic children. The seropositive rate of toxocariasis in hyper-eosinophilic children (>1000/mm3) was 15.1%, while the seropositivity was 4.1% in children with eosinophilia status (500-999/mm3). There was a significant association between the eosinophilia rate and seropositivity (P<0.05). Also, seroprevalence in asymptomatic eosinophilic children was 4.4%, while in children with clinical symptoms it was 17.1%. Accordingly, a statistically significant difference was found between clinical symptoms and infection (P<0.05).
CONCLUSION
The prevalence of toxocariasis in eosinophilic children is a serious health problem in the study area. Therefore, serologic evaluation for the diagnosis of infection is recommended for eosinophilic children.
背景
旋毛虫病是一种由旋毛形线虫引起的严重动物源性蠕虫病。
目的
本研究旨在确定 2019-2020 年期间伊朗西北部卡齐凡省儿科医院就诊的嗜酸粒细胞增多症患儿的旋毛虫病血清流行率及相关危险因素。
方法
共采集 200 份嗜酸粒细胞增多症患儿的血样。收集人口统计学数据、临床症状和犬类及土壤接触史。采用 IgG ELISA 试剂盒检测抗 IgG 抗体。
结果
在所有嗜酸粒细胞增多症患儿中，有 14 例（7%）检测到抗 IgG 抗体。高嗜酸性粒细胞（>1000/mm3）患儿的旋毛虫病血清阳性率为 15.1%，而嗜酸性粒细胞增多症患儿（500-999/mm3）的血清阳性率为 4.1%。嗜酸性粒细胞比率与血清阳性率之间存在显著相关性（P<0.05）。此外，无症状嗜酸粒细胞增多症患儿的血清阳性率为 4.4%，而有临床症状的患儿的血清阳性率为 17.1%。因此，临床症状与感染之间存在统计学显著差异（P<0.05）。
结论
在研究地区，嗜酸粒细胞增多症患儿的旋毛虫病流行率是一个严重的健康问题。因此，建议对嗜酸粒细胞增多症患儿进行血清学评估以诊断感染。
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