Baya Bocar, Kone Bourahima, Somboro Amadou, Kodio Ousmane, Somboro Anou Moise, Diarra Bassirou, Traore Fah Gaoussou, Kone Drissa, Traore Mama Adama, Kone Mahamadou, Togo Antieme Georges, Sarro Yeya Sadio, Maiga Almoustapha, Maiga Mamoudou, Toloba Yacouba, Diallo Souleymane, Murphy Robert L, Doumbia Seydou
University Clinical Research Center (UCRC) of the University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Service of Pneumopthisiology of the University Teaching Hospital of Point G, Bamako, Mali.
Open J Epidemiol. 2023 Feb;13(1):97-111. doi: 10.4236/ojepi.2023.131008. Epub 2023 Feb 23.
Tuberculosis disease stands for the second leading cause of death worldwide after COVID-19, most active tuberculosis cases result from the reactivation of latent TB infection through impairment of immune response. Several factors are known to sustain that process. , a parasite of the helminth genus that possesses switching power from an immune profile type Th1 to Th2 that favors reactivation of latent TB bacteria. The aim of the study was to assess the prevalence of the co-infection between the two endemic infections. Systematic literature was contacted at the University Clinical Research Center at the University of Sciences, Techniques, and Technologies of Bamako in Mali. Original articles were included, and full texts were reviewed to assess the prevalence and better understand the immunological changes that occur during the co-infection. In total, 3530 original articles were retrieved through database search, 53 were included in the qualitative analysis, and data from 10 were included in the meta-analysis. Prevalence of the co-infection ranged from 4% to 34% in the literature. Most of the articles reported that immunity against infection with helminth parasite and more specifically infection enhances latent TB reactivation through Th1/Th2. In sum, the impact of co-infection with is under-investigated. Understanding the role of this endemic tropical parasite as a contributing factor to TB epidemiology and burden could help integrate its elimination as one of the strategies to achieve the END-TB objectives by the year 2035.
结核病是全球仅次于新冠疫情的第二大致死原因，大多数活动性结核病病例是由于免疫反应受损导致潜伏性结核感染重新激活所致。已知有几个因素会促使这一过程发生。 ，一种蠕虫属寄生虫，具有从免疫Th1型转变为Th2型的能力，这有利于潜伏性结核杆菌的重新激活。本研究的目的是评估这两种地方性感染合并感染的患病率。在马里巴马科科学、技术与工艺大学的大学临床研究中心检索了系统文献。纳入了原始文章，并对全文进行了综述，以评估患病率，并更好地了解合并感染期间发生的免疫变化。通过数据库搜索总共检索到3530篇原始文章，53篇纳入定性分析，10篇的数据纳入荟萃分析。文献中合并感染的患病率在4%至34%之间。大多数文章报告说，针对蠕虫寄生虫感染的免疫力，更具体地说是 感染，通过Th1/Th2增强潜伏性结核的重新激活。总之， 与 的合并感染的影响研究不足。了解这种地方性热带寄生虫作为结核病流行病学和负担的一个促成因素的作用，有助于将其消除作为实现2035年终结结核病目标的战略之一。
