Baya Bocar, Diarra Bassirou, Dabitao Djeneba Koumba, Somboro Amadou, Traore Fah Gaoussou, Goita Drissa, Coulibaly Gagni, Sanogo Moumine, Wague Mamadou, Kone Bourahima, Kone Drissa, Ouattara Khadidia, Soumare Dianguina, Kanoute Tenin, Toloba Yacouba, Maiga Almoustapha I, Maiga Mamoudou, Diallo Souleymane, Murphy Robert L, Doumbia Seydou
University Clinical Research Center (UCRC).
Department of Clinical Laboratory.
Res Sq. 2024 Sep 8:rs.3.rs-4796634. doi: 10.21203/rs.3.rs-4796634/v1.
People with Latent tuberculosis infection (LTBI) remain the reservoir of tuberculosis. One-third to 1/4 of the world's population is infected. Its reactivation is due to factors that disrupt the host's immune response. Recent findings showed that coinfection leads to a Th2/Th1 profile which results in an immune modulation that favors the escape of the Mycobacteria. may contribute to TB incidence in endemic regions. We aimed to investigate the co-infection rate and patient outcomes.
A prospective cohort study was conducted between 2020-2022 at University Clinical Research Center (UCRC), including culture-confirmed active pulmonary TB patients and tested for in stools using Kato-Katz Technique. After descriptive analysis a logistic regression was performed to determine risk factors associated with TB and co-infection.
Data of 174 tuberculosis-confirmed patients, Kato-Katz tested were analyzed. Males represented 62.6%, mean age was 34.9 ± 13.8 years, 29.9% were smokers, alcohol consumption 13.8%, TB contact history 26.4%, HIV coinfection 11.5%, diabetes 6.3%, undernourished 55.7%. prevalence was 28.7%. The co-infection was associated with less lung cavitation [aOR = 0.24 [95% CI (0.06-0.85), p = 0.028], unfavorable treatment result [aOR = 2.95 (1.23-7.08), p = 0.015] and death [aOR = 3.43 (1.12-10.58), p = 0.032].
Despite Kato-Katz's low sensitivity, coinfection was found in one-third of the TB patients; 2.5-fold higher than that of HIV. The coinfection was associated with poor treatment results and death.
潜伏性结核感染（LTBI）患者仍是结核病的传染源。全球三分之一至四分之一的人口受到感染。其复发归因于破坏宿主免疫反应的因素。最近的研究结果表明，合并感染会导致Th2/Th1细胞因子谱，从而引起免疫调节，有利于分枝杆菌逃逸，这可能是流行地区结核病发病率上升的原因。我们旨在调查合并感染率及患者的预后情况。
2020年至2022年期间，在大学临床研究中心（UCRC）进行了一项前瞻性队列研究，纳入痰培养确诊的活动性肺结核患者，并采用加藤厚涂片法检测粪便中的寄生虫。在进行描述性分析后，进行逻辑回归分析以确定与结核病及合并感染相关的危险因素。
对174例确诊结核病患者且经加藤厚涂片法检测的数据进行了分析。男性占62.6%，平均年龄为34.9±13.8岁，29.9%为吸烟者，13.8%饮酒，26.4%有结核病接触史，11.5%合并感染HIV，6.3%患糖尿病，55.7%营养不良。寄生虫感染率为28.7%。合并感染与较少的肺空洞形成相关[aOR = 0.24 [95% CI（0.06 - 0.85），p = 0.028]、不良治疗结果相关[aOR = 2.95（1.23 - 7.08），p = 0.015]以及死亡相关[aOR = 3.43（1.12 - 10.58），p = 0.032]。
尽管加藤厚涂片法的敏感性较低，但在三分之一的结核病患者中发现了寄生虫合并感染；这一比例比HIV合并感染高2.5倍。合并感染与治疗效果不佳及死亡相关。
