Cansel Neslihan, Turkmen Dursun, Altunisik Nihal
Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkiye.
Department of Dermatology, Inonu University Faculty of Medicine, Malatya, Turkiye.
North Clin Istanb. 2023 Feb 20;10(1):79-86. doi: 10.14744/nci.2021.10170. eCollection 2023.
Chronic urticaria (CU) is a common skin disease in which the etiology involves immunological and psychological factors. Childhood traumas may disrupt the development of the neuro-immuno-cutaneous-endocrine system and start a complex pathophysiological process with inflammatory abnormalities, potentially leading to the development of skin disease. In light of this information, we believe that childhood trauma may play a role in the onset and severity of disease in CU patients. Our study aimed to discover a potential relationship between CU and childhood traumatic experiences.
This study was conducted with 53 controls and 50 CU patients. The participants were given a questionnaire form that included sociodemographic information, Beck Anxiety Scale, Beck Depression Scale, and Childhood Trauma Questionnaire (CTQ-28).
The rates of childhood trauma were found to be 68% in the patient group, and 54.7% in the control group. The patient group demonstrated higher scores for moderate to severe anxiety and depression. The mean emotional abuse score was significantly higher in early onset (<35 ages) urticaria patients in comparison to late onset urticarial (≥35 ages) and the control group. It was found that depression scores were positively correlated with all abuse sub-types, excluding sexual abuse, and total CTQ-28 scores. Anxiety scores were positively correlated with emotional abuse, physical neglect, emotional neglect, and total CTQ-28 scores.
Childhood traumas are associated with the early onset and severity of disease in CU patients as well as the accompanying depression and anxiety.
慢性荨麻疹（CU）是一种常见的皮肤病，其病因涉及免疫和心理因素。童年创伤可能会扰乱神经-免疫-皮肤-内分泌系统的发育，并引发一个伴有炎症异常的复杂病理生理过程，有可能导致皮肤病的发生。鉴于此信息，我们认为童年创伤可能在CU患者疾病的发作和严重程度中起作用。我们的研究旨在发现CU与童年创伤经历之间的潜在关系。
本研究对53名对照者和50名CU患者进行。参与者被给予一份问卷，其中包括社会人口统计学信息、贝克焦虑量表、贝克抑郁量表和儿童创伤问卷（CTQ-28）。
患者组童年创伤发生率为68%，对照组为54.7%。患者组中度至重度焦虑和抑郁得分更高。与迟发性荨麻疹（≥35岁）患者及对照组相比，早发性（<35岁）荨麻疹患者的平均情感虐待得分显著更高。研究发现，抑郁得分与除性虐待外的所有虐待亚型及CTQ-28总分呈正相关。焦虑得分与情感虐待、身体忽视、情感忽视及CTQ-28总分呈正相关。
童年创伤与CU患者疾病的早发和严重程度以及伴随的抑郁和焦虑有关。
