沙特阿拉伯西南部人群中UCP2 - 866 G/A基因型与自身免疫性甲状腺功能减退症的关联
The Association of UCP2-866 G/A Genotype with Autoimmune Hypothyroidism in the Southwestern Saudi Arabia Population.
作者信息
Habibullah Mahmoud M, Hakamy Ali, Mansor Abdullah S, Atti Ibrahim Mohammed, Alwadani Abbas Ali Jaber, Kaabi Yahia A
机构信息
Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Medical Research Center, Jazan University, Jazan, Saudi Arabia.
出版信息
Int J Gen Med. 2023 Mar 6;16:875-879. doi: 10.2147/IJGM.S400424. eCollection 2023.
INTRODUCTION
Autoimmune hypothyroidism (AHT) is a widespread disease that disproportionately affects women over men. It is characterized by the presence of autoantibodies that lead to the dysfunction of the thyroid gland. The exact cause of this process is unknown; however, some factors, such as genetic factors, may be to blame. encodes uncoupling protein 2, which has been linked to several pathogeneses; however, the link between UCP2-866 G/A polymorphism and AHT has yet to be investigated. Thus, we investigate the potential relationship between UCP2-866 G/A polymorphism and AHT.
METHODS
A total of 158 subjects participated in this study, they were either control or AHT patient, and genotyping was performed using a polymerase chain reaction.
RESULTS
The frequencies of UCP2-866 G/G, G/A, and A/A in the control subject were 34%, 51%, and 15%, respectively, whereas these frequencies in the AHT were 43%, 46%, and 10%.
CONCLUSION
The study concludes a significant relationship between UCP2-866 G/A polymorphism and AHT, with a carrier subject of the -866 A allele being 3 times more likely to suffer from AHT than wild-type carriers in the study population.
引言
自身免疫性甲状腺功能减退症（AHT）是一种广泛存在的疾病，女性受其影响的比例高于男性。其特征是存在导致甲状腺功能障碍的自身抗体。这一过程的确切原因尚不清楚；然而，一些因素，如遗传因素，可能是罪魁祸首。UCP2基因编码解偶联蛋白2，该蛋白与多种发病机制有关；然而，UCP2 - 866 G/A多态性与AHT之间的联系尚未得到研究。因此，我们研究了UCP2 - 866 G/A多态性与AHT之间的潜在关系。
方法
共有158名受试者参与了本研究，他们要么是对照组，要么是AHT患者，并使用聚合酶链反应进行基因分型。
结果
对照组中UCP2 - 866 G/G、G/A和A/A的频率分别为34%、51%和15%，而在AHT组中这些频率分别为43%、46%和10%。
结论
该研究得出结论，UCP2 - 866 G/A多态性与AHT之间存在显著关系，在研究人群中，携带 - 866 A等位基因的受试者患AHT的可能性是野生型携带者的3倍。
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