Habibullah Mahmoud M, Hurubi Ali, Hakamy Ali O, Alwadani Abbas Ali Jaber, Atti Ibrahim Mohammed, Alothaid Hani, Shamlan Ghalia, Aldughaim Mohammed, Kaabi Yahia A, Alhazmi Alaa, Hamali Hassan
Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Nursing Department, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Diabetes Metab Syndr Obes. 2024 Nov 30;17:4593-4598. doi: 10.2147/DMSO.S493459. eCollection 2024.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, which results in initiates oxidative stress and disrupts various cellular pathways. In this study, we examined the relationship between polymorphisms in antioxidant enzymes, specifically glutathione peroxidase 1 (GPx1) and catalase (CAT), and the susceptibility to T2DM in a Saudi population from the Jazan Province.
A total of 419 participants were evaluated, including 247 T2DM patients and 172 controls. They were genotyped for the GPx1 Pro198Leu and CAT-262C/T polymorphisms by a PCR-based method.
The results indicated that individuals with the CAT T/T genotype had a 60% lower likelihood of developing T2DM compared with those harboring the C/C genotype (uOD 0.4; 95% CI 0.2-0.8, p = 0.04); however, no significant association was observed between the GPx1 polymorphism and T2DM.
The results suggest that CAT polymorphism may confer a protective effect against T2DM, whereas the GPx1 polymorphism appears not to be a determinant of T2DM susceptibility in this population. Further studies including larger and more diverse cohorts are necessary to validate these results and elucidate the underlying mechanisms. Understanding the genetic factors that contribute to T2DM is essential for developing targeted preventive and therapeutic strategies.
2型糖尿病（T2DM）是一种慢性代谢紊乱疾病，其特征为持续性高血糖，这会引发氧化应激并扰乱各种细胞通路。在本研究中，我们调查了抗氧化酶（特别是谷胱甘肽过氧化物酶1（GPx1）和过氧化氢酶（CAT））基因多态性与沙特阿拉伯吉赞省人群患T2DM易感性之间的关系。
共评估了419名参与者，包括247名T2DM患者和172名对照。通过基于聚合酶链反应（PCR）的方法对他们进行GPx1 Pro198Leu和CAT - 262C/T基因分型。
结果表明，与携带C/C基因型的个体相比，具有CAT T/T基因型的个体患T2DM的可能性低60%（优势比0.4；95%置信区间0.2 - 0.8，p = 0.04）；然而，未观察到GPx1基因多态性与T2DM之间存在显著关联。
结果表明，CAT基因多态性可能对T2DM具有保护作用，而在该人群中，GPx1基因多态性似乎不是T2DM易感性的决定因素。需要进一步开展包括更大规模和更多样化队列的研究来验证这些结果并阐明潜在机制。了解导致T2DM的遗传因素对于制定有针对性的预防和治疗策略至关重要。
