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从静脉注射改用皮下注射达雷妥尤单抗的益处:英国医疗服务提供者的观点。

Benefits of switching from intravenous to subcutaneous daratumumab: Perspectives from UK healthcare providers.

作者信息

Cook Gordon, Ashcroft John, Fernandez Mariana, Henshaw Sarah, Khalaf Zeyad, Pratt Guy, Tailor Anish, Rabin Neil

机构信息

Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom.

Department of Haematology, St James's University Hospital, Leeds, United Kingdom.

出版信息

Front Oncol. 2023 Feb 23;13:1063144. doi: 10.3389/fonc.2023.1063144. eCollection 2023.

Abstract

Daratumumab is a CD38-directed monoclonal antibody indicated to treat multiple myeloma (MM). Daratumumab was initially administered intravenously (IV), subsequently a subcutaneous (SC) formulation was developed to increase convenience of administration. The UK was an early adopter of SC daratumumab and, as such, this report provides consensus recommendations from a group of UK MM experts, with the aim of facilitating the transition from IV to SC daratumumab for other European healthcare providers. The switch from IV to SC daratumumab has been beneficial to patients and healthcare providers, as it simplifies treatment, reduces pressure on hospitals and can improve patients' quality of life.

摘要

达雷妥尤单抗是一种靶向CD38的单克隆抗体,用于治疗多发性骨髓瘤(MM)。达雷妥尤单抗最初通过静脉注射给药,随后开发了皮下注射剂型以提高给药便利性。英国是皮下注射达雷妥尤单抗的早期采用者,因此,本报告提供了一组英国MM专家的共识建议,旨在促进其他欧洲医疗服务提供者从静脉注射达雷妥尤单抗过渡到皮下注射达雷妥尤单抗。从静脉注射达雷妥尤单抗转换为皮下注射达雷妥尤单抗对患者和医疗服务提供者都有益,因为它简化了治疗,减轻了医院的压力,并可以提高患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5dd/9996301/bc14550ce2d0/fonc-13-1063144-g001.jpg

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