Wang Qinghua, Sun Song, Lu Shui, Hu Renjing, Sun Hongjuan, Gu Yan, Zhang Zhengwei
Department of Ophthalmology, Affiliated Wuxi Clinical College of Nantong University, Wuxi, Jiangsu 214002, P.R. China.
Department of Ophthalmology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China.
Exp Ther Med. 2023 Feb 20;25(4):157. doi: 10.3892/etm.2023.11856. eCollection 2023 Apr.
The present study aimed to examine the clinical and pathogenic characteristics, diagnosis and treatment of primary canaliculitis to provide further guidance for its clinical management. The present prospective study enrolled 50 patients (50 eyes) diagnosed with primary canaliculitis between May 2018 and April 2021 at Department of Ophthalmology, Affiliated Wuxi Clinical College of Nantong University, Wuxi, China. The patients' general clinicopathological information, clinical characteristics, microbiological profiles and treatment outcomes were analyzed and summarized. All the patients presented with persistent red eyes and eye discharge. Examination of discharge smears revealed that 96% of patients tested positive for and all smears were negative for fungi. Microbial cultures indicated that 82% of cases were positive for bacteria. A total of 51 bacterial strains were cultured; of these, 27.5% were aerobes, 35.3% were anaerobes and 37.2% were facultative anaerobes. A total of 56.9% of strains were gram-positive and 43.1% were gram-negative. The three most common bacteria, including spp spp. and , were analyzed. Only 3 cases (6%) of microbial cultures were positive for and all cases were negative for fungi in microbial cultures. Among the 50 cases, 45 were cured with conservative treatment [intracanalicular ointment infiltration (IOI)]. Five patients responded poorly to conservative treatment; however, they were cured with surgical treatment. In the current study, the majority of canaliculitis cases were caused by mixed infections, predominantly . The results revealed that the culture positivity rate of was low; however, the smear staining positivity rate was high. Fungus was smear- and culture-negative in all cases. In conclusion, patients with canaliculitis had a good prognosis after timely diagnosis and treatment.
本研究旨在探讨原发性泪小管炎的临床及致病特征、诊断与治疗方法，为其临床管理提供进一步指导。本前瞻性研究纳入了2018年5月至2021年4月在中国无锡南通大学附属无锡临床学院眼科诊断为原发性泪小管炎的50例患者（50只眼）。分析并总结了患者的一般临床病理信息、临床特征、微生物学特征及治疗结果。所有患者均有持续性眼红和眼部分泌物。分泌物涂片检查显示，96%的患者检测出[具体病菌未给出]阳性，所有涂片真菌检测均为阴性。微生物培养表明，82%的病例细菌培养阳性。共培养出51株细菌；其中，27.5%为需氧菌，35.3%为厌氧菌，37.2%为兼性厌氧菌。共56.9%的菌株为革兰氏阳性菌，43.1%为革兰氏阴性菌。分析了三种最常见的细菌，包括[具体细菌种类未给出]。微生物培养中仅3例（6%）检测出[具体病菌未给出]阳性，所有病例真菌培养均为阴性。50例患者中，45例经保守治疗[泪小管内眼膏浸润（IOI）]治愈。5例患者对保守治疗反应不佳；然而，他们经手术治疗后治愈。在本研究中，大多数泪小管炎病例由混合感染引起，主要是[具体病菌未给出]。结果显示，[具体病菌未给出]的培养阳性率较低；然而，涂片染色阳性率较高。所有病例真菌涂片及培养均为阴性。总之，泪小管炎患者经及时诊断和治疗后预后良好。
