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在一名患有难治性抑郁症和精神共病的患者中，右美沙芬/安非他酮联合治疗对自杀未遂后的抑郁症状有改善作用。

Improvement of depressive symptoms, after a suicide attempt, with dextromethorphan/bupropion combination treatment in a patient with treatment-resistant depression and psychiatric comorbidities.

作者信息

Pedraz-Petrozzi Bruno, Deuschle Michael, Gilles Maria

机构信息

Department of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg Mannheim Germany.

出版信息

Clin Case Rep. 2023 Mar 7;11(3):e7045. doi: 10.1002/ccr3.7045. eCollection 2023 Mar.

DOI:10.1002/ccr3.7045
PMID:36911631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9992139/
Abstract

We admitted a 42-year-old patient with severe treatment-resistant depression and with psychiatric comorbidities. The patient attempted suicide 5 weeks after admission. Subsequently, we initiated dextromethorphan/bupropion based on prior evidence. As a result, the patient demonstrated an improvement in mood symptoms and a reduction in suicide risk, leading to her discharge.

摘要

我们收治了一名42岁患有严重难治性抑郁症且伴有精神疾病共病的患者。该患者在入院5周后试图自杀。随后，我们根据先前的证据开始使用右美沙芬/安非他酮。结果，患者的情绪症状有所改善，自杀风险降低，随后出院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9410/9992139/ae7c617bf61b/CCR3-11-e7045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9410/9992139/ae7c617bf61b/CCR3-11-e7045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9410/9992139/ae7c617bf61b/CCR3-11-e7045-g001.jpg

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本文引用的文献

1
Dextromethorphan/Bupropion: First Approval.右美沙芬/安非他酮：首次批准。
CNS Drugs. 2022 Nov;36(11):1229-1238. doi: 10.1007/s40263-022-00968-4.
2
Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story?了解右美沙芬-安非他酮组合的疗效及作用机制：在N-甲基-D-天冬氨酸（NMDA）与μ阿片类药物的理论中它处于什么位置？
Am J Psychiatry. 2022 Jul;179(7):448-450. doi: 10.1176/appi.ajp.20220434.
3
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI).
AXS-05（右美沙芬-安非他酮）治疗重度抑郁症患者的疗效和安全性：一项 3 期随机临床试验（GEMINI）。
J Clin Psychiatry. 2022 May 30;83(4):21m14345. doi: 10.4088/JCP.21m14345.
4
Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial.AXS-05（右美沙芬-安非他酮）治疗重性抑郁障碍的疗效：一项随机、双盲对照试验。
Am J Psychiatry. 2022 Jul;179(7):490-499. doi: 10.1176/appi.ajp.21080800. Epub 2022 May 18.
5
Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials.右美沙芬治疗抑郁症的疗效：临床前和临床试验的系统评价。
Expert Opin Emerg Drugs. 2021 Mar;26(1):63-74. doi: 10.1080/14728214.2021.1898588. Epub 2021 Mar 12.
6
Dextromethorphan/Bupropion: A Novel Oral NMDA (N-methyl-d-aspartate) Receptor Antagonist with Multimodal Activity.右美沙芬/安非他酮：一种具有多模态活性的新型口服 NMDA（N-甲基-D-天冬氨酸）受体拮抗剂。
CNS Spectr. 2019 Oct;24(5):461-466. doi: 10.1017/S1092852919001470.
7
Treatment Resistant Depression with Loss of Antidepressant Response: Rapid-Acting Antidepressant Action of Dextromethorphan, A Possible Treatment Bridging Molecule.抗抑郁反应丧失的难治性抑郁症：右美沙芬的快速抗抑郁作用，一种可能的治疗桥梁分子。
Psychopharmacol Bull. 2016 Aug 15;46(2):53-58.
8
Psychiatric comorbidities in patients with major depressive disorder.重度抑郁症患者的精神共病
Neuropsychiatr Dis Treat. 2014 Nov 10;10:2097-103. doi: 10.2147/NDT.S72026. eCollection 2014.
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Am J Psychiatry. 2006 Nov;163(11):1905-17. doi: 10.1176/ajp.2006.163.11.1905.