银催化的α-亚氨基-氧代酸环化反应合成并四氢酮衍生物。
Silver-catalyzed cyclization of α-imino-oxy acids to fused tetralone derivatives.
机构信息
School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun 113001, China.
College of Food Science and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang 277160, China.
出版信息
Org Biomol Chem. 2023 Mar 29;21(13):2700-2704. doi: 10.1039/d2ob02329f.
A silver-catalyzed intramolecular radical relay cyclization of α-imino-oxy acids under mild conditions has been described. This reaction offers facile access to a diverse range of fused tetralone derivatives with exquisite stereoselectivity in moderate to good yields (40-98%). Experimental studies show that the reaction undergoes a decarboxylation and acetone fragmentation/1,5-hydrogen atom transfer (HAT)/cyclization process.
描述了一种在温和条件下，通过α-亚氨基-氧代酸的银催化分子内自由基接力环化反应。该反应以中等至良好的收率（40-98%），简便地获得了具有极好的立体选择性的各种稠合四氢萘酮衍生物。实验研究表明，该反应经历脱羧和丙酮断裂/1,5-氢原子转移（HAT）/环化过程。
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