Cerner Enviza, Malvern, PA, USA.
Merck & Co., Inc, Rahway, NJ, USA.
AIDS Care. 2023 Oct;35(10):1542-1554. doi: 10.1080/09540121.2023.2185195. Epub 2023 Mar 13.
With advances in the treatment of HIV, people living with HIV (PLWH) are now expected to have a near-normal life expectancy, but challenges remain in the form of substantially poorer health-related quality of life (HRQoL) than the general population. Being overweight or obese may pose an additional burden in PLWH, but few studies have evaluated the relationship between body mass index (BMI) and HRQoL in PLWH. This study aimed to evaluate and describe the association between HRQoL and BMI among PLWH in the US. Data were obtained from the 2018 and 2019 US National Health and Wellness Survey, an online, self-reported, general population survey. Analyses included 575 PLWH who self-reported a physician diagnosis and prescription use for the treatment of HIV, as well as 1725 propensity score matched non-HIV controls. After adjusting for age, sex, race, and comorbidities, higher BMI was associated with poorer physical (β = -0.18, = 0.005) and general (β = -0.42, = 0.014) HRQoL among PLWH. Additionally, PLWH reported poorer mental, physical, and general HRQoL than non-HIV controls; these relationships were not moderated by BMI. The potential negative impact of higher BMI on patients' humanistic outcomes should be considered in HIV management, including selection of treatment.
随着 HIV 治疗的进展，HIV 感染者（PLWH）现在有望拥有接近正常的预期寿命，但仍面临与普通人群相比健康相关生活质量（HRQoL）显著较差的挑战。超重或肥胖可能会给 PLWH 带来额外的负担，但很少有研究评估 BMI 与 PLWH 中的 HRQoL 之间的关系。本研究旨在评估和描述美国 PLWH 中的 HRQoL 与 BMI 之间的关联。数据来自 2018 年和 2019 年的美国国家健康和健康调查，这是一项在线、自我报告的一般人群调查。分析包括 575 名自我报告医生诊断和处方治疗 HIV 的 PLWH ，以及 1725 名匹配倾向得分的非 HIV 对照者。在调整年龄、性别、种族和合并症后，较高的 BMI 与 PLWH 的身体（β=−0.18，=0.005）和一般（β=−0.42，=0.014）HRQoL 较差相关。此外，PLWH 报告的心理、身体和一般 HRQoL 均差于非 HIV 对照者；这些关系不受 BMI 的调节。在 HIV 管理中，包括治疗选择，应考虑较高 BMI 对患者的人文结局的潜在负面影响。
