Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China.
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.
Org Lett. 2023 Mar 24;25(11):1958-1962. doi: 10.1021/acs.orglett.3c00464. Epub 2023 Mar 13.
A visible-light-induced radical -iodoallylation of CFCHN was developed under mild conditions, delivering a variety of α-CF-substituted homoallylic iodide compounds in moderate to excellent yields. The transformation features broad substrate scope, good functional group compatibility, and operational simplicity. The described protocol provides a convenient and attractive tool to apply CFCHN as CF-introduction reagent in radical synthetic chemistry.
可见光诱导的 CFCHN 的自由基 - 碘代烯丙基化反应在温和条件下发展起来，以中等至优秀的产率得到了多种 α-CF 取代的偕二碘代烯丙基化合物。该转化具有广泛的底物范围、良好的官能团兼容性和操作简单的特点。所描述的方案为 CFCHN 作为自由基合成化学中 CF 引入试剂的应用提供了一种方便而有吸引力的工具。
