Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark.
Osteoporos Int. 2023 May;34(5):935-942. doi: 10.1007/s00198-023-06720-y. Epub 2023 Mar 13.
Osteoporosis in men may be underdiagnosed. One in four men in Denmark will develop osteoporosis after age of 50 years, with fracture as a common presenting symptom.
The aim of this study was to describe epidemiology of male osteoporosis in Denmark.
In this nationwide registry-based cohort study, we identified men with osteoporosis, 50 years or older, residing in Denmark, during the years 1996-2018. Osteoporosis was defined as one of the following: a hospital diagnosis of osteoporosis; a hospital diagnosis of osteoporosis fracture; or an outpatient dispensing of an anti-osteoporosis medication. We reported annual incidence and prevalence and described the distribution of fractures, comorbidities, socioeconomic status, and initiation of anti-osteoporosis therapy among men with osteoporosis. Selected characteristics were also described among men without osteoporosis of similar age.
There were 171,186 men fulfilling the study criteria for osteoporosis. The overall age-standardized incidence rate of osteoporosis was 8.6 per 1000 person-years (95% confidence interval (CI), 8.5-8.6), varying between 7.7 and 9.7, while the prevalence increased from 4.3% (95% CI, 4.2-4.3) to 7.1% (95% CI, 7.0-7.1) during the 22-year period. The remaining-lifetime risk of developing osteoporosis after age of 50 years was close to 30%. The proportion of men initiating anti-osteoporosis treatment within 1 year of diagnosis increased from 6.9% to 29.8%. Men with osteoporosis had more comorbidities and redeemed more medication than did men without osteoporosis of similar age.
Osteoporosis among men may be undertreated despite increasing treatment initiation.
男性骨质疏松症可能诊断不足。丹麦四分之一的男性在 50 岁后会患上骨质疏松症，骨折是常见的表现症状。
本研究旨在描述丹麦男性骨质疏松症的流行病学情况。
在这项基于全国登记的队列研究中，我们确定了年龄在 50 岁及以上、居住在丹麦的男性骨质疏松症患者。骨质疏松症的定义为以下之一：医院诊断为骨质疏松症；医院诊断为骨质疏松性骨折；或门诊开出抗骨质疏松药物。我们报告了男性骨质疏松症的年发病率和患病率，并描述了骨折、合并症、社会经济状况和抗骨质疏松症治疗的起始情况。还描述了年龄相似但没有骨质疏松症的男性的一些特征。
有 171186 名男性符合骨质疏松症的研究标准。骨质疏松症的总体年龄标准化发病率为 8.6/1000 人年（95%置信区间[CI]，8.5-8.6），在 7.7 至 9.7 之间变化，而患病率在 22 年期间从 4.3%（95%CI，4.2-4.3）增加到 7.1%（95%CI，7.0-7.1）。50 岁后发生骨质疏松症的终身风险接近 30%。在诊断后 1 年内开始抗骨质疏松症治疗的男性比例从 6.9%增加到 29.8%。患有骨质疏松症的男性比年龄相似但没有骨质疏松症的男性有更多的合并症和更多的药物处方。
尽管治疗开始增加，但男性骨质疏松症的治疗可能不足。
