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砂拉越总医院骨质疏松性髋部骨折的性别差异。

Gender differences in osteoporotic hip fractures in Sarawak General Hospital.

机构信息

Sarawak General Hospital, Rheumatology Unit, Sarawak, Malaysia.

Sarawak General Hospital, Geriatrics Unit, Sarawak, Malaysia.

出版信息

Med J Malaysia. 2023 Mar;78(2):207-212.

Abstract

INTRODUCTION

Osteoporosis and osteoporotic fracture pose a major public health problem in our ageing population, and particularly concerning is the increased morbidity and mortality associated with osteoporotic hip fractures. While overall diagnosis and treatment for osteoporosis have improved, osteoporosis in men remains underdiagnosed and undertreated. We aim to describe the difference in clinical characteristics between elderly men and women with osteoporotic hip fractures in Sarawak General Hospital.

MATERIALS AND METHODS

All patients diagnosed with osteoporotic hip fracture admitted to Sarawak General Hospital from June 2019 to March 2021 were recruited, and demographic data and clinical features were obtained.

RESULTS

There were 140 patients with osteoporotic hip fracture, and 40 were men (28.6%). The mean age for males was 74.1 ± 9.5 years, while the mean age for females was 77.4 ± 9.1 years (p=0.06). The types of fracture consisted of neck of femur=78, intertrochanteric=61 and subtrochanteric=1. More men were active smokers (15% vs 1%, p<0.001). There were 20 men with secondary osteoporosis (50%), while 13 women (13%) had secondary osteoporosis (p<0.001). The causes of secondary osteoporosis among the men were hypogonadism, COPD, glucocorticoid-induced osteoporosis, renal disease, androgen deprivation therapy, thyroid disorder, prostate cancer and previous gastrectomy. There were two deaths among the men and four deaths among the women during the inpatient and 3 months follow-up period. There was no statistical significance between the mortality rates between male patients (5%) and female patients (4%) (p=0.55).

CONCLUSION

There were more females with osteoporotic hip fractures, and there were significantly more males with secondary osteoporotic hip fractures.

摘要

简介

骨质疏松症和骨质疏松性骨折是我们老龄化人口面临的主要公共卫生问题,尤其令人担忧的是与骨质疏松性髋部骨折相关的发病率和死亡率增加。尽管骨质疏松症的整体诊断和治疗有所改善,但男性骨质疏松症仍未得到充分诊断和治疗。我们旨在描述砂拉越总医院老年男性和女性骨质疏松性髋部骨折患者的临床特征差异。

材料和方法

所有 2019 年 6 月至 2021 年 3 月期间因骨质疏松性髋部骨折入住砂拉越总医院的患者均被招募,并获得了人口统计学数据和临床特征。

结果

共有 140 例骨质疏松性髋部骨折患者,其中 40 例为男性(28.6%)。男性的平均年龄为 74.1±9.5 岁,而女性的平均年龄为 77.4±9.1 岁(p=0.06)。骨折类型包括股骨颈骨折=78 例,转子间骨折=61 例和转子下骨折=1 例。更多男性是活跃吸烟者(15%比 1%,p<0.001)。有 20 例男性为继发性骨质疏松症(50%),而 13 例女性(13%)患有继发性骨质疏松症(p<0.001)。男性继发性骨质疏松症的病因包括性腺功能减退症、COPD、糖皮质激素诱导的骨质疏松症、肾脏疾病、雄激素剥夺治疗、甲状腺疾病、前列腺癌和既往胃切除术。男性中有 2 例死亡,女性中有 4 例死亡,均发生在住院期间和 3 个月随访期间。男性患者(5%)和女性患者(4%)的死亡率之间没有统计学意义(p=0.55)。

结论

女性骨质疏松性髋部骨折患者较多,且男性继发性骨质疏松性髋部骨折患者明显较多。

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