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近期在泌尿外科急症患者中开具阿片类药物的处方趋势。

Recent trends in the prescription of opioids in the emergency department in patients with urolithiasis.

机构信息

Mount Sinai Medical Center, Columbia University Division of Urology, 4302 Alton Road, Suite 540, Miami Beach, FL, 33140, USA.

Departments of Socio-Behavioral-Administrative Pharmacy, and Pharmaceutical Sciences, Nova Southeastern University, Davie, FL, USA.

出版信息

Int Urol Nephrol. 2023 May;55(5):1109-1116. doi: 10.1007/s11255-023-03545-w. Epub 2023 Mar 13.

Abstract

PURPOSE

Pain management is central in the treatment of urolithiasis. We aimed to estimate the impact of the 2017 Department of Health and Human Services declaration of an opioid crisis on prescribing patterns of opioids and NSAIDs in emergency department visits for urolithiasis.

METHODS

The National Health Ambulatory Medical Care Survey (NHAMCS) was queried for emergency department visits of adults with a diagnosis of urolithiasis. The association between urolithiasis and narcotic and NSAIDs prescription patterns was evaluated and compared at pre-declaration (2014-2016) to post-declaration (2017-2018) periods.

RESULTS

Opioids were prescribed in about 211 million (41.1%) out of 513 million emergency department visits, over a 5-year period. Diagnosis of urolithiasis accounted for 1.9% of the visits (6.0 million). The use of opioids was higher in urolithiasis (82.7%) compared to non-urolithiasis diagnosis (40.3%), as well as the use of multiple opioids per visit (p < 0.01 for all). There was an overall decrease in opioid prescriptions in the post-declaration period, - 4.3% for urolithiasis (p = 0.254) and - 5.6% for non-urolithiasis visits (p < 0.05). A decrease in the use of hydromorphone (- 47.5%. p < 0.001), an increase in the use of morphine (+ 59.7% p = 0.006), and an increase of 'other' opioids (+ 98.8%, p < 0.041), were observed. Opioids combined with NSAIDs comprised 72.6% of the opioid prescriptions and 62.3% of all analgesic prescriptions in visits with urolithiasis diagnosis.

CONCLUSIONS

The use of opioids when managing urolithiasis decreased 4.3% after the crisis declaration; however, statistically are not different from pre-declaration numbers. Most often, opioids were prescribed with NSAIDs in urolithiasis patients.

摘要

目的

疼痛管理是尿路结石治疗的核心。我们旨在评估 2017 年美国卫生与公众服务部宣布阿片类药物危机对急诊尿路结石就诊中阿片类药物和 NSAIDs 处方模式的影响。

方法

通过国家卫生门诊医疗调查(NHAMCS)查询成人尿路结石诊断的急诊就诊情况。评估并比较声明前(2014-2016 年)和声明后(2017-2018 年)时期尿路结石与阿片类药物和 NSAIDs 处方模式之间的关联。

结果

在 5 年期间,5.13 亿次急诊就诊中约有 2.11 亿次(41.1%)开具了阿片类药物。尿路结石诊断占就诊量的 1.9%(600 万次)。与非尿路结石诊断(40.3%)相比,尿路结石就诊中阿片类药物的使用率更高(82.7%),且每次就诊使用的阿片类药物种类更多(所有比较 p<0.01)。声明后,阿片类药物处方总体减少,尿路结石减少 4.3%(p=0.254),非尿路结石就诊减少 5.6%(p<0.05)。氢吗啡酮的使用减少了(-47.5%,p<0.001),吗啡的使用增加了(+59.7%,p=0.006),其他阿片类药物的使用增加了(+98.8%,p<0.041)。在尿路结石就诊中,阿片类药物联合 NSAIDs 占阿片类药物处方的 72.6%,占所有镇痛药物处方的 62.3%。

结论

在危机声明后,尿路结石管理中阿片类药物的使用减少了 4.3%;然而,与声明前的数字相比没有统计学差异。在尿路结石患者中,阿片类药物通常与 NSAIDs 一起开具。

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