微管结构，四分之一个世纪以后。

The tubulin structure, a quarter of a century later.

机构信息

Molecular and Cell Biology Department, University of California, Berkeley.

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory.

出版信息

Mol Biol Cell. 2023 Apr 1;34(4):rt2. doi: 10.1091/mbc.E23-01-0005.

DOI:10.1091/mbc.E23-01-0005

PMID:36913319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10092645/

Abstract

This retrospective on the 25th anniversary of the publication of the first structure of tubulin is shaped by my own personal experiences rather than being a strict and complete historical account of the event. It is a reflection on how working in science felt many years ago, on the struggles and the joys of reaching for the high-hanging fruit, and, ultimately, on how relevant or not our personal scientific contributions are to the broader scientific community. Writing it brought back memories of my unique and sadly lost postdoctoral advisor Ken Downing, who dreamt of this structure and brought it to fruition against all odds.

摘要

这篇关于第一篇微管蛋白结构发表 25 周年的回顾文章，是基于我个人的亲身经历撰写的，而不是对这一事件的严格和完整的历史记录。它反映了多年前从事科学工作的感受，反映了为高挂的果实而奋斗的艰辛和喜悦，以及最终我们个人的科学贡献与更广泛的科学界有多么相关或不相关。写这篇文章让我想起了我独特而不幸失去的博士后导师肯·唐宁，他梦想着这个结构，并克服重重困难使之成为现实。