Max Planck Institute for Brain Research, Frankfurt, Germany; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Denmark; Aarhus University, Department of Molecular Biology and Genetics, Universitetsbyen 81, 8000 Aarhus C, Denmark. Electronic address: https://twitter.com/LukeChaoSun.
Max Planck Institute for Brain Research, Frankfurt, Germany.
Curr Opin Neurobiol. 2023 Jun;80:102705. doi: 10.1016/j.conb.2023.102705. Epub 2023 Mar 11.
While it has long been known that protein synthesis is necessary for long-term memory in the brain, the logistics of neuronal protein synthesis is complicated by the extensive subcellular compartmentalization of the neuron. Local protein synthesis solves many of the logistic problems posed by the extreme complexity of dendritic and axonal arbors and the huge number of synapses. Here we review recent multi-omic and quantitative studies that elaborate a systems view of decentralized neuronal protein synthesis. We highlight recent insights from the transcriptomic, translatomic, and proteomic levels, discuss the nuanced logic of local protein synthesis for different protein features, and list the missing information needed to build a comprehensive logistic model for neuronal protein supply.
虽然长期以来人们一直知道蛋白质合成对于大脑中的长期记忆是必要的，但神经元蛋白质合成的物流问题由于神经元的广泛细胞内区室化而变得复杂。局部蛋白质合成解决了树突和轴突树突的极端复杂性以及大量突触所带来的许多物流问题。在这里，我们回顾了最近的多组学和定量研究，这些研究详细阐述了分散的神经元蛋白质合成的系统观点。我们重点介绍了来自转录组、转原子组和蛋白质组水平的最新见解，讨论了局部蛋白质合成对于不同蛋白质特征的细微逻辑，并列出了构建神经元蛋白质供应综合物流模型所需的缺失信息。
