Chernichenko I A
Eksp Onkol. 1987;9(5):53-6.
The data on the carcinogenic activity of different benz(a)pyrene (BP) doses depending on the mode of administration are presented. Carcinogen was introduced to 418 female mice in the doses from 0.5 to 10 mg intratracheally, perorally or simultaneously. It is established that the complex administration of BP is more dangerous as compared with the intratracheal and with the peroral one, which was indicated by an increase of the tumour incidence and in a shortening of the latent period. Calculation of the contribution or a share of the complex dose from the isoeffective value under isolated entry of BP has shown that the coefficient of complex action is 0.6, that evidences for the effect of the dose potentiating.
本文展示了不同剂量苯并(a)芘（BP）根据给药方式的致癌活性数据。致癌物质以0.5至10毫克的剂量通过气管内、口服或同时给药的方式引入418只雌性小鼠体内。结果表明，与气管内给药和口服给药相比，BP联合给药更具危险性，这表现为肿瘤发病率增加和潜伏期缩短。根据BP单独给药时等效应值计算联合剂量的贡献或份额，结果显示联合作用系数为0.6，这证明了剂量增强效应。
