Meng Yuting, Mao Yu, Tang Zhongxiang, Qiu Xiangjie, Bajinka Ousman, Tan Yurong, Song Zhi
Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China.
Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China.
Microb Pathog. 2023 May;178:106062. doi: 10.1016/j.micpath.2023.106062. Epub 2023 Mar 11.
The human microbiome is a complex ecosystem that mediates interaction between the human host and the environment. All of the human body is colonized by microorganisms. The lung as an organ used to be considered sterile. Recently, however, there has been a growing number of reports with evidence that the lungs are also in a state of carrying bacteria. The pulmonary microbiome is associated with many lung diseases and is increasingly reported in current studies. These include; chronic obstructive pulmonary disease (COPD), asthma, acute chronic respiratory infections, and cancers. These lung diseases are associated with reduced diversity and dysbiosis. It directly or indirectly affects the occurrence and development of lung cancer. Very few microbes directly cause cancer, while many are complicit in cancer growth, usually working through the host's immune system. This review focuses on the correlation between lung microbiota and lung cancer, and investigates the mechanism of action of lung microorganisms on lung cancer, which will provide new and reliable treatments and diagnosis of lung cancer in the future.
人类微生物组是一个复杂的生态系统，它介导人类宿主与环境之间的相互作用。人体的所有部位都有微生物定植。肺作为一个器官，过去被认为是无菌的。然而，最近有越来越多的报道并有证据表明肺部也处于携带细菌的状态。肺部微生物组与许多肺部疾病相关，并且在当前研究中越来越多地被报道。这些疾病包括慢性阻塞性肺疾病（COPD）、哮喘、急慢性呼吸道感染和癌症。这些肺部疾病与多样性降低和生态失调有关。它直接或间接影响肺癌的发生和发展。很少有微生物直接导致癌症，而许多微生物则在癌症生长中起协同作用，通常是通过宿主的免疫系统发挥作用。本综述重点关注肺部微生物群与肺癌之间的相关性，并研究肺部微生物对肺癌的作用机制，这将为未来肺癌的治疗和诊断提供新的可靠方法。
