Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education; College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
ACS Sens. 2023 Mar 24;8(3):1192-1199. doi: 10.1021/acssensors.2c02574. Epub 2023 Mar 13.
Plasmonic nanostructures have a desirable surface-enhanced Raman scattering (SERS) response related to particle spacing. However, precisely controlling the distance of plasmonic nanostructures is still a challenge. DNA has the merit of specific recognition, and flexible modification of functional groups, which can be used to flexibly adjust the gaps between plasmonic nanostructures for improving the stability of SERS. In this paper, DNA-guided gold nanoparticles formed one-dimensional ordered structures and they were self-assembled at the water-oil interface by a bottom-up approach. Notably, an output switching strategy successfully transfers a small amount of target into a large amount of reporter DNA; thereby, Raman probes are captured on the sensing interface and achieve the SERS assay of microRNA 155 (miRNA-155). This study is an exciting strategy for obtaining ordered plasmonic structures and providing surveillance, which is important for the clinical diagnosis of early-stage cancer.
等离子体纳米结构具有与粒子间距相关的理想表面增强拉曼散射（SERS）响应。然而，精确控制等离子体纳米结构的距离仍然是一个挑战。DNA 具有特异性识别和功能基团灵活修饰的优点，可用于灵活调节等离子体纳米结构之间的间隙，以提高 SERS 的稳定性。在本文中，DNA 引导的金纳米粒子形成了一维有序结构，并通过自下而上的方法在油水界面上自组装。值得注意的是，一种输出切换策略成功地将少量靶标转化为大量报告 DNA；从而，拉曼探针被捕获在传感界面上，并实现了 microRNA 155（miRNA-155）的 SERS 测定。这项研究为获得有序等离子体结构和提供监测提供了令人兴奋的策略，这对癌症早期的临床诊断很重要。
