Department of Chemistry, Zhejiang University, Hangzhou, 310028, P.R. China.
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457, Singapore.
Chembiochem. 2019 Oct 1;20(19):2432-2441. doi: 10.1002/cbic.201900191. Epub 2019 Jul 2.
Surface-enhanced Raman scattering (SERS), with greatly amplified fingerprint spectra, holds great promise in biochemical and biomedical research. In particular, the possibility of exciting a library of SERS probes and differentially detecting them simultaneously has stimulated widespread interest in multiplexed biodetection. Herein, recent progress in developing SERS-active plasmonic nanostructures for cellular and intracellular detection is summarized. The development of nanosensors with tailored plasmonic and multifunctional properties for profiling molecular and pathological processes is highlighted. Future challenges towards the routine use of SERS technology in quantitative bioanalysis and clinical diagnostics are further discussed.
表面增强拉曼散射（SERS）具有极大增强的指纹光谱，在生物化学和生物医学研究中具有广阔的应用前景。特别是，通过激发 SERS 探针库并同时进行差分检测的可能性，激发了人们对多重生物检测的广泛兴趣。本文总结了用于细胞内和细胞内检测的 SERS 活性等离子体纳米结构的最新进展。重点介绍了具有定制等离子体和多功能特性的纳米传感器在分析分子和病理过程方面的发展。进一步讨论了 SERS 技术在定量生物分析和临床诊断中的常规应用所面临的未来挑战。
