柯蒂氏器传感机制中的行为特征。

Behavioral characteristics in sensing mechanism of the Corti.

作者信息

Liang Junyi, Wang Jiakun, Yao Wenjuan, Zhou Lei, Huang Xinsheng

机构信息

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.

Shanghai Institute of Applied Mathematics and Mechanics, Shanghai 200072, PR China.

出版信息

Comput Struct Biotechnol J. 2023 Feb 18;21:1797-1806. doi: 10.1016/j.csbj.2023.02.030. eCollection 2023.

DOI:10.1016/j.csbj.2023.02.030

PMID:36915377

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10006463/

Abstract

Some experiments can't be realized because the cochlea's Corti is the most delicate and complex sensory organ. In this paper, some typical and special behavioral characteristics in the process of sensation were found in medical clinic. Based on the interdisciplinary principles of medicine, physics and biology, a real numerical simulation model of Corti is established. On the basis of verifying the correctness of the model, the mechanism corresponding to these typical and special behavior characteristics in the process of sensation is explored through simulation calculation and analysis. This study provides theoretical and applied basis for people to better understand the sound sensing mechanism, and provides a numerical simulation platform for further analyzing Corti's sensing mechanism and good clinical application.

摘要

由于耳蜗的柯蒂氏器是最精细和复杂的感觉器官，一些实验无法实现。本文在医学临床中发现了感觉过程中的一些典型和特殊行为特征。基于医学、物理学和生物学的跨学科原理，建立了柯蒂氏器的真实数值模拟模型。在验证模型正确性的基础上，通过模拟计算和分析探索了感觉过程中这些典型和特殊行为特征对应的机制。本研究为人们更好地理解声音感知机制提供了理论和应用基础，并为进一步分析柯蒂氏器的感知机制及良好的临床应用提供了数值模拟平台。