Li Jun, Han Ying
Department of Integrated Traditional Chinese and Western Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan 430010, Hubei, China.
Am J Transl Res. 2023 Feb 15;15(2):1360-1366. eCollection 2023.
To investigate the effect of modified Xiaoqinglong Decoction on cough variant asthma (CVA) and immunological functioning in children.
In this is retrospective analysis, 122 children with CAV admitted to our hospital from Mar. 2021 to Mar. 2022 were divided into an observation group (n=61) and a control group (n=61) according to treatment methods. The control group received fluticasone propionate inhalation aerosol, and the observation group additionally received Xiaoqinglong Decoction. The therapeutic efficacy in the two groups was compared after 8 weeks of treatment. The comparison indictors included scores of daytime and nighttime cough, pulmonary function, fractional exhaled nitric oxide (FeNO), eosinophil count, inflammatory response (interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and macrophage inflammatory protein ((MIP)-1α), immunoglobulin (Ig)) level and adverse reactions.
The overall response rate of children with CVA in the observation group was higher than that in the control group (). After treatment, the scores of daytime and nighttime cough in the observation group were lower than those in the control group (). The Forced Vital Capacity (FVC), peak expiratory flow (PEF) and FEV1 (Forced Expiratory Volume)/FVC of the observation group were higher than those in the control group (). The FeNO and eosinophil count in the observation group were lower than those in the control group (). The serum IL-4 was higher, while TNF-α and MIP-1α levels were lower in the observation group in the control group (). The serum IgA, IgG and IgM levels in the observation group were higher than those in the control group ().
The modified Xiaoqinglong Decoction has a conspicuous effect on children with CVA. It helps to reduce cough symptoms, improve pulmonary function, reduce inflammatory response and improve immunological functioning of children.
探讨加味小青龙汤对小儿咳嗽变异性哮喘（CVA）及免疫功能的影响。
本研究为回顾性分析，将2021年3月至2022年3月我院收治的122例CAV患儿按治疗方法分为观察组（n = 61）和对照组（n = 61）。对照组吸入丙酸氟替卡松气雾剂，观察组在此基础上加用小青龙汤。治疗8周后比较两组的治疗效果。比较指标包括白天和夜间咳嗽评分、肺功能、呼出一氧化氮分数（FeNO）、嗜酸性粒细胞计数、炎症反应（白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）和巨噬细胞炎性蛋白（（MIP）-1α））水平、免疫球蛋白（Ig）水平及不良反应。
观察组CVA患儿的总有效率高于对照组（）。治疗后，观察组白天和夜间咳嗽评分低于对照组（）。观察组的用力肺活量（FVC）、呼气峰值流速（PEF）和第1秒用力呼气容积（FEV1）/FVC高于对照组（）。观察组的FeNO和嗜酸性粒细胞计数低于对照组（）。观察组血清IL-4较高，而TNF-α和MIP-1α水平低于对照组（）。观察组血清IgA、IgG和IgM水平高于对照组（）。
加味小青龙汤对小儿CVA有显著疗效。有助于减轻咳嗽症状，改善肺功能，减轻炎症反应，提高小儿免疫功能。
