Wang Houhong, Gong Huihui, Tang Amao, Cui Yayun
Department of General Surgery, The Affiliated Bozhou Hospital of Anhui Medical University Bozhou 236800, Anhui, China.
Faculty of Health and Life Sciences, Oxford Brookes University Oxford OX3 0BP, United Kingdom.
Am J Transl Res. 2023 Feb 15;15(2):1412-1420. eCollection 2023.
To identify the independent risk factors of gastric cancer (GC) lymph node metastasis and to determine whether the preoperative neutrophil and lymphocyte ratio (NLR) and the platelet and lymphocyte ratio (PLR) can be used as the indicators of gastric cancer lymph node metastasis.
The pathological data of 221 patients with gastric cancer were retrospectively analyzed, and the risk factors of lymph node metastasis were evaluated. The relationship between preoperative NLR and PLR and the clinical pathology of patients were analyzed, and the effect of these two indexes on lymph node metastasis was predicted through receiver operating characteristic (ROC) curve.
Lymph node metastasis correlated with tumor diameter, depth of invasion, Tumor-Node-Metastasis (TNM) stage, preoperative NLR and preoperative PLR (all P<0.05), but not with gender, age and tumor location (all P>0.05). According to the result of multivariate analysis, the degree of differentiation, depth of invasion, TNM staging and NLR were independent risk factors for GC lymph node metastasis.
The sensitivity and specificity of PLR, tumor staging and tumor size are lower than NLR. Preoperative NLR can be used as an independent risk factor for the prediction of lymph node metastasis, and one of the effective indicators for predicting the prognosis of patients. Preoperative NLR may be an effective auxiliary tool to assess lymph nodes in GC patients.
确定胃癌（GC）淋巴结转移的独立危险因素，并判断术前中性粒细胞与淋巴细胞比值（NLR）及血小板与淋巴细胞比值（PLR）是否可作为胃癌淋巴结转移的指标。
回顾性分析221例胃癌患者的病理资料，评估淋巴结转移的危险因素。分析术前NLR和PLR与患者临床病理的关系，并通过受试者工作特征（ROC）曲线预测这两个指标对淋巴结转移的影响。
淋巴结转移与肿瘤直径、浸润深度、肿瘤-淋巴结-转移（TNM）分期、术前NLR和术前PLR相关（均P<0.05），但与性别、年龄和肿瘤位置无关（均P>0.05）。多因素分析结果显示，分化程度、浸润深度、TNM分期和NLR是GC淋巴结转移独立危险因素。
PLR、肿瘤分期和肿瘤大小的敏感性和特异性低于NLR。术前NLR可作为预测淋巴结转移的独立危险因素及预测患者预后的有效指标之一。术前NLR可能是评估GC患者淋巴结的有效辅助工具。
