The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu 223800, PR China.
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, PR China.
Aging (Albany NY). 2024 May 13;16(10):8541-8551. doi: 10.18632/aging.205820.
The aim of this study was to investigate the main factors influencing the survival of patients with advanced gastric cancer.
The clinicopathological data of 120 patients with advanced gastric cancer were analyzed retrospectively, and clinical and pathological data were collected. Tumor tissue staging and grading were re-evaluated, and 5-year overall survival was followed up. The classified data were described by percentages, and the continuous data were described by standard deviations or medians. Univariate analysis was performed using the χ test or rank-sum test, followed by Kaplan-Meier survival analysis to calculate the median survival time and 5-year cumulative survival. A multivariate Cox regression model was used to evaluate the independent risk factors affecting survival. The test level was α = 0.05.
Patients were followed up for 0 to 60 months, the 5-year overall survival rate was 36.2%, and the median survival time was 53.0 ± 1.461 months. K-M and log-rank test results revealed that tumor location, degree of differentiation, depth of invasion, regional lymph node involvement, and postoperative tumor stage were correlated with a decreased 5-year survival rate ( < 0.05). A multivariate Cox risk regression model was used to analyze the degree of histological differentiation (HR = 1.441; 95% CI = 1.049-1.979; = 0.024), regional lymph node (HR = 1.626; 95% CI = 1.160-2.279; = 0.005), and pTNM stage (HR = 2.266; 95% CI = 1.335-3.847; = 0.002), which are independent risk factors for poor survival. Tumor location ( = 0.191), invasion depth ( = 0.579) and tumor size ( = 0.324) were not found to be independent risk factors.
The degree of tumor differentiation, regional lymph node metastasis and postoperative pathological stage were found to be independent risk factors for 5-year overall survival in patients with advanced gastric cancer. Standardized and reasonable lymph node dissection and accurate postoperative pathological staging were very important.
本研究旨在探讨影响晚期胃癌患者生存的主要因素。
回顾性分析 120 例晚期胃癌患者的临床病理资料，收集临床和病理资料。重新评估肿瘤组织分期和分级，随访 5 年总生存率。分类数据用百分比描述，连续数据用标准差或中位数描述。采用 χ²检验或秩和检验进行单因素分析，然后进行 Kaplan-Meier 生存分析计算中位生存时间和 5 年累积生存率。采用多因素 Cox 回归模型评估影响生存的独立危险因素。检验水准α=0.05。
患者随访 060 个月，5 年总生存率为 36.2%，中位生存时间为 53.0±1.461 个月。K-M 和对数秩检验结果显示，肿瘤部位、分化程度、浸润深度、区域淋巴结转移和术后肿瘤分期与 5 年生存率降低相关（<0.05）。采用多因素 Cox 风险回归模型分析组织学分化程度（HR=1.441；95%CI=1.0491.979；=0.024）、区域淋巴结（HR=1.626；95%CI=1.1602.279；=0.005）和 pTNM 分期（HR=2.266；95%CI=1.3353.847；=0.002）是生存不良的独立危险因素。肿瘤部位（=0.191）、浸润深度（=0.579）和肿瘤大小（=0.324）未发现是独立危险因素。
肿瘤分化程度、区域淋巴结转移和术后病理分期是影响晚期胃癌患者 5 年总生存率的独立危险因素。规范化、合理的淋巴结清扫和准确的术后病理分期非常重要。
