绘制胞葬作用研究的知识结构和新兴趋势：一项文献计量分析。
Mapping the knowledge structure and emerging trends of efferocytosis research: a bibliometric analysis.
作者信息
Lv Hao, Hua Qingquan, Wang Yunfei, Gao Ziang, Liu Peiqiang, Qin Danxue, Xu Yu
机构信息
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University Wuhan, Hubei, China.
Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University Wuhan, Hubei, China.
出版信息
Am J Transl Res. 2023 Feb 15;15(2):1386-1402. eCollection 2023.
BACKGROUND
Efferocytosis refers to the physiological clearance process of apoptotic cells by specialized and non-phagocytes and it is essential in human health and disease. However, there is a lack of comprehensive and objective reports on the current status of efferocytosis research. Here, we visually analyzed the hotspots and trending issues of efferocytosis research with bibliometric analysis.
METHODS
Relevant publications were obtained from the Web of Science Core Collection on February 18, 2022. We performed bibliometric and visual analysis using CiteSpace, VOSviewer, Microsoft Excel 2019, and the online Bibliometric platform.
RESULTS
A total of 1007 publications on efferocytosis were retrieved. The number of efferocytosis studies increased rapidly from 2006 to 2021. The country that published the most efferocytosis related articles was the USA and the most productive institutions were Harvard University and Brigham and Women's Hospital. The most prolific and influential author was I. Tabas of Columbia University. Frontiers in Immunology published the most research papers on efferocytosis, the while Journal of Immunology had the highest co-citation frequency. The high-frequency keywords were "efferocytosis", "inflammation", "apoptotic cells", "macrophages", and "apoptosis". The analysis of keywords with the strongest citation bursts identified "cell" and "resolution" as emerging hotspots.
CONCLUSION
Our results demonstrated that efferocytosis research increased steadily within the past decade. Current efferocytosis studies focus on three main aspects: mechanisms, basic biology, and potential role in disease. The research trends included the cellular players of the efferocytosis process and the role of efferocytosis in inflammation resolution. This bibliometric analysis presented a comprehensive overview of efferocytosis research and provided valuable references and ideas for scholars interested in this field.
背景
胞葬作用是指凋亡细胞被特殊细胞和非吞噬细胞进行生理性清除的过程，对人类健康和疾病至关重要。然而，目前缺乏关于胞葬作用研究现状的全面且客观的报道。在此，我们运用文献计量学分析对胞葬作用研究的热点和趋势问题进行可视化分析。
方法
于2022年2月18日从科学引文索引核心合集获取相关出版物。我们使用CiteSpace、VOSviewer、Microsoft Excel 2019以及在线文献计量平台进行文献计量和可视化分析。
结果
共检索到1007篇关于胞葬作用的出版物。从2006年到2021年，胞葬作用研究的数量迅速增加。发表胞葬作用相关文章最多的国家是美国，产出最多的机构是哈佛大学和布莱根妇女医院。最多产且最具影响力的作者是哥伦比亚大学的I. 塔巴斯。《免疫学前沿》发表的关于胞葬作用的研究论文最多，而《免疫学杂志》的共被引频次最高。高频关键词为“胞葬作用”“炎症”“凋亡细胞”“巨噬细胞”和“凋亡”。对具有最强引文爆发的关键词分析确定“细胞”和“消退”为新兴热点。
结论
我们的结果表明，在过去十年中胞葬作用研究稳步增加。当前胞葬作用研究集中在三个主要方面：机制、基础生物学以及在疾病中的潜在作用。研究趋势包括胞葬作用过程中的细胞参与者以及胞葬作用在炎症消退中的作用。这项文献计量分析全面概述了胞葬作用研究，并为该领域感兴趣的学者提供了有价值的参考和思路。
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