Zhou Qian, Wu Fei, Zhao Mingyi, Yang Minghua
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Cell Dev Biol. 2022 Jan 18;9:793347. doi: 10.3389/fcell.2021.793347. eCollection 2021.
Ferroptosis is an iron-dependent regulated cell-death caused by the accumulation of lipid peroxides, which is different from apoptosis, autophagy, necroptosis and other forms of regulatory cell death in morphology and mechanism. It has attracted interest and attention of scholars from all over the world during the past years. Recent studies have shown that ferroptosis is able to play a clear and important role in cancer treatment, providing a bright prospect for targeted cancer therapy. This article aims to analyze current scientific results about the application of ferroptosis in the field of cancer treatment, providing new ideas for further research. We retrieved publications related to ferroptosis and cancer treatment from 2012 to 2020 from the Web of Science Core Collection (WoSCC), screening them according to the inclusion criteria. A total of 965 related papers were included, and the total number of publications increased year by year. We used CiteSpace 5.7. R2, VOSviewer and Microsoft Excel 2019 to evaluate and visualize the results, analyzing institutions, countries/regions, journals, authors, co-cited reference and keywords. Overall, with more and more evidence showing the indispensable role of ferroptosis in cancer, its mechanism research and target discovery may become the main direction of future research.
铁死亡是一种由脂质过氧化物积累引起的铁依赖性调节性细胞死亡，在形态和机制上与凋亡、自噬、坏死性凋亡等其他形式的调节性细胞死亡不同。在过去几年中，它引起了世界各地学者的兴趣和关注。最近的研究表明，铁死亡在癌症治疗中能够发挥明确且重要的作用，为癌症靶向治疗提供了光明的前景。本文旨在分析当前关于铁死亡在癌症治疗领域应用的科学成果，为进一步研究提供新思路。我们从科学引文索引核心合集（WoSCC）中检索了2012年至2020年与铁死亡和癌症治疗相关的出版物，并根据纳入标准进行筛选。共纳入965篇相关论文，且出版物总数逐年增加。我们使用CiteSpace 5.7.R2、VOSviewer和Microsoft Excel 2019对结果进行评估和可视化，分析机构、国家/地区、期刊、作者、共被引参考文献和关键词。总体而言，随着越来越多的证据表明铁死亡在癌症中不可或缺的作用，其机制研究和靶点发现可能成为未来研究的主要方向。
