Perucca E, Parini J, Albrici A, Visconti M, Ferrero E
Institute of Medical Pharmacology, University of Pavia, Italy.
Eur J Drug Metab Pharmacokinet. 1987 Apr-Jun;12(2):145-8. doi: 10.1007/BF03189889.
The kinetics of the nootropic drug oxiracetam was studied in 6 elderly female patients (age range 69-96 years) in good physical condition. After a single oral dose (800 mg), serum oxiracetam levels reached a peak (25 +/- 6 micrograms/ml) within 1-3 h and declined thereafter with a half-life of 3 to 6 h. Eighty-four percent of the administered dose was recovered in urine as unchanged drug within 24 h. During a maintenance regimen (800 b.i.d. at 8 a.m. and 2 p.m.) for 7 days oxiracetam did not show any accumulation in serum, trough serum levels before the morning and afternoon doses being 4.6 +/- 2.3 and 17.0 +/- 8.2 micrograms/ml respectively on day 4 and 5.7 +/- 3.3 and 17.9 +/- 7.7 micrograms/ml respectively on day 7. Comparison with previous pharmacokinetic data obtained in young subjects suggests that the clearance of the drug is lower in the elderly, probably as a result of the physiological decrease in renal function in old age.
对6名身体状况良好的老年女性患者（年龄范围69 - 96岁）进行了促智药奥拉西坦的动力学研究。单次口服剂量（800毫克）后，血清奥拉西坦水平在1 - 3小时内达到峰值（25±6微克/毫升），此后下降，半衰期为3至6小时。24小时内，84%的给药剂量以原形药物形式在尿液中回收。在维持治疗方案（每天上午8点和下午2点各800毫克，共7天）期间，奥拉西坦在血清中未显示任何蓄积，第4天上午和下午给药前的谷浓度分别为4.6±2.3和17.0±8.2微克/毫升，第7天分别为5.7±3.3和17.9±7.7微克/毫升。与先前在年轻受试者中获得的药代动力学数据相比，表明老年人中该药物的清除率较低，这可能是由于老年时肾功能生理性下降所致。
