Banfi S, Dorigotti L
Clin Neuropharmacol. 1986;9 Suppl 3:S19-26.
Oxiracetam (4-hydroxy-2-oxo-1-pyrrolidine acetamide) is a novel compound effective in improving learning and memory in normal animals as well as in animals with acute cerebral impairment induced by a variety of noxious stimuli (i.e., electroshock, neurodepressants, metabolic inhibitors, hypoxia). In accordance with a stepwise approach to the pharmacological studies, the compound was also tested in rats with chronic cerebral impairment due to aging, cerebrovascular lesions, and congenital microencephaly. To evaluate the brain telencephalic functions, the learning rate of two conditioned avoidance responses using the pole climbing test and the performance in a multiple-choice water maze were considered. Oxiracetam at doses ranging from 10 to 60 mg/kg i.p. improved the learning rate of these animals with impaired cognitive functions. The compound was active also by oral administration.
奥拉西坦（4-羟基-2-氧代-1-吡咯烷乙酰胺）是一种新型化合物，对正常动物以及由多种有害刺激（如电休克、神经抑制剂、代谢抑制剂、缺氧）诱导的急性脑损伤动物的学习和记忆改善有效。按照药理学研究的逐步方法，该化合物也在因衰老、脑血管病变和先天性小头畸形而患有慢性脑损伤的大鼠中进行了测试。为了评估脑端脑功能，考虑了使用爬杆试验的两种条件回避反应的学习率和在多项选择水迷宫中的表现。腹腔注射剂量为10至60mg/kg的奥拉西坦提高了这些认知功能受损动物的学习率。该化合物口服给药也有活性。
