Chen Yulin, Fang Mingyu, Ke Yi
Department of Pathology, The Affiliated Hospital of Putian University, Putian, China.
Department of Ultrasound, The Affiliated Hospital of Putian University, Putian, China.
Gland Surg. 2023 Feb 28;12(2):252-262. doi: 10.21037/gs-23-13. Epub 2023 Feb 15.
The aim of this study was to investigate the expression of insulin receptor (IR) in the blood vessels of patients with breast cancer (BC) with or without type 2 diabetes mellitus (DM2) and its relationship with histopathological features of BC tissues and patient prognosis.
A total of 124 patients with BC diagnosed and treated at The Affiliated Hospital of Putian University between January 2018 and January 2019 were eligible for this study. According to the presence or absence of DM2, they were then divided into 2 groups: patients with BC and DM2 (DBC group, n=26) and patients with BC and without DM2 (BC group, n=98). The expression of IR in the cancer and adjacent tissues was detected using immunohistochemistry. The patients were followed up for 1 year. Kaplan-Meier analysis was used to compute the overall survival (OS) of the patients with BC. Furthermore, Cox regression was employed to investigate the correlation of IR expression with DM2, pathological tissue, TNM stage, and OS.
IR expression in cancer tissues (34.7%) was significantly higher than that in adjacent normal tissues (15.3%). Among cancer tissues, IR was highly expressed in DBC tissues (57.7%) compared with BC tissues (28.6%). IR was also highly expressed in patients with tumor infiltration and lymphatic metastasis. Its expression was significantly correlated with T stage and N stage, but not with M stage. In addition, patients with high IR expression had significantly lower survival than did those with low IR expression. Moreover, univariate and multivariate Cox regression analysis indicated that tumor infiltration, lymphatic metastasis, tumor size, T stage, and high IR expression were independent risk factors for BC prognosis.
High IR expression was associated with poor prognosis of patients with BC. The expression of IR may be a promising indicator to assess the survival of patients with BC.
本研究旨在调查伴或不伴2型糖尿病（DM2）的乳腺癌（BC）患者血管中胰岛素受体（IR）的表达情况及其与BC组织病理特征和患者预后的关系。
2018年1月至2019年1月在莆田学院附属医院确诊并接受治疗的124例BC患者符合本研究条件。根据是否患有DM2，将他们分为2组：BC合并DM2患者（DBC组，n = 26）和BC不合并DM2患者（BC组，n = 98）。采用免疫组织化学法检测癌组织及癌旁组织中IR的表达。对患者进行1年随访。采用Kaplan-Meier分析计算BC患者的总生存期（OS）。此外，采用Cox回归分析IR表达与DM2、病理组织、TNM分期和OS的相关性。
癌组织中IR的表达（34.7%）显著高于癌旁正常组织（15.3%）。在癌组织中，与BC组织（28.6%）相比，DBC组织中IR高表达（57.7%）。IR在肿瘤浸润和淋巴结转移患者中也高表达。其表达与T分期和N分期显著相关，但与M分期无关。此外，IR高表达患者的生存率显著低于IR低表达患者。而且，单因素和多因素Cox回归分析表明，肿瘤浸润、淋巴结转移、肿瘤大小、T分期和IR高表达是BC预后的独立危险因素。
IR高表达与BC患者预后不良相关。IR的表达可能是评估BC患者生存情况的一个有前景的指标。
