Pharmacokinetics of cefotaxime and its desacetyl metabolite in plasma and in cerebrospinal fluid.
作者信息
Beyssac E, Cardot J M, Colnet G, Sirot J, Aiache J M
机构信息
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
出版信息
Eur J Drug Metab Pharmacokinet. 1987 Apr-Jun;12(2):91-102. doi: 10.1007/BF03189882.
PMID:3691581
Abstract
The aim of the study was to investigate the pharmacokinetic modelling of Cefotaxime (CTX) and its main metabolite Desacetyl Cefotaxime (DCTX) which has a less antibacterial activity than the CTX. After intravenous administration of 1g of CTX to 26 patients, the plasma concentrations determined by HPLC showed that the pharmacokinetics of CTX and transformation to DCTX can be described with an open five-compartment model. The implications of this are discussed from the clinical point of view.
摘要
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