Florindo Claudia, Mimoso Jorge M, Palma Sandra L, Gonçalves Carolina, Silvestre Daniela, Campinho Marco, Tavares Álvaro A
Faculty of Medicine and Biomedical Sciences. University of Algarve.
Centre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal.
MicroPubl Biol. 2023 Feb 24;2023. doi: 10.17912/micropub.biology.000762. eCollection 2023.
Mob4 is an essential evolutionary conserved protein shown to play roles in cell division and neural development. Mob4 is a core component of the macromolecular STRIPAK complex involved in various critical cellular processes, from cell division to signal transduction pathways. However, Mob4 remains relatively poorly understood. Although the consequences of eliminating Mob4 function in Drosophila are described, its function in vertebrate development remains largely unknown. Here we show that knockdown and knockout of Mob4 during zebrafish embryogenesis limits neuronal cell divisions but has little effect on apoptosis, thus arguing a role for mob4 in neurodevelopment.
Mob4是一种在进化上保守的必需蛋白，已证明其在细胞分裂和神经发育中发挥作用。Mob4是大分子STRIPAK复合物的核心成分，该复合物参与从细胞分裂到信号转导途径等各种关键的细胞过程。然而，人们对Mob4的了解仍然相对较少。尽管已经描述了在果蝇中消除Mob4功能的后果，但其在脊椎动物发育中的功能仍然很大程度上未知。在这里，我们表明，在斑马鱼胚胎发育过程中敲低和敲除Mob4会限制神经元细胞分裂，但对细胞凋亡影响不大，因此表明mob4在神经发育中发挥作用。
