Tfelt-Hansen P, Jansen I, Edvinsson L
Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
Eur J Clin Pharmacol. 1987;33(1):77-9. doi: 10.1007/BF00610384.
Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine.
甲基麦角新碱是麦角酸二乙胺的主要代谢产物，在人颞动脉离体节段中，其5-羟色胺拮抗效力比麦角酸二乙胺大40倍。有人提出，在偏头痛预防中使用麦角酸二乙胺时，甲基麦角新碱才是“活性”药物，并且这两种化合物应在偏头痛预防试验中进行比较。
