Spierings E L, Saxena P R
Neurology. 1980 Jul;30(7 Pt 1):696-701. doi: 10.1212/wnl.30.7.696.
The effects of three antimigraine drugs--ergotamine, dihydroergotamine, and methysergide--on the distribution of flow throughout the cephalic circulation of the cat were studied, using microspheres of a suitable size to separate capillary flow from flow through the arteriovenous anastomoses. Ergotamine and dihydroergotamine significantly decreased the fraction of carotid blood flow shunted through the arteriovenous anastomoses, a mode of action that reemphasizes the need for further clinical studies on the involvement of arteriovenous anastomoses in the pathophysiology of migraine headaches.
研究了三种抗偏头痛药物——麦角胺、双氢麦角胺和甲基麦角新碱——对猫头部循环中血流分布的影响，使用合适大小的微球体将毛细血管血流与通过动静脉吻合支的血流区分开来。麦角胺和双氢麦角胺显著降低了通过动静脉吻合支分流的颈动脉血流比例，这种作用方式再次强调了有必要对动静脉吻合支参与偏头痛病理生理学进行进一步的临床研究。
