Otong Eduitem Sunday, Makena Wusa, Solomon Abel Yashim, Bazabang Sebastine Anthony, Aminu Aisha, Henry Rachael
Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Abubakar Tafawa Balewa University, Bauchi, Bauchi State, Nigeria.
Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria.
Environ Anal Health Toxicol. 2022 Dec;37(4):e2022027-0. doi: 10.5620/eaht.2022027. Epub 2022 Oct 5.
Mercury chloride (HgCl2) is a neurotoxicant that remains a health hazard despite numerous efforts to reduce its levels in the environment. The use of medicinal plants in treating various diseases and other toxic agents has grown popular owing to their effectiveness and affordable rates. Andrographis paniculata (A. paniculata) is a plant with astringent and detoxifying characteristics and is widely used worldwide for its medicinal and antioxidant benefits. This study aimed to investigate the possible protective effects of A. paniculata aqueous extract against HgCl2-induced memory impairment, oxidative stress, and brain damage. Twenty-five adult Wistar rats were randomly divided into five groups: control, HgCl2 0.5 mg/kg, HgCl2+AP 250 mg/kg, HgCl2+AP 500 mg/kg, or HgCl2+Ascorbic acid 200 mg/kg. For 28 days, administrations were given through oral gavage once a day. HgCl2 injection resulted in memory impairment, increased glutamate concentrations in the brain, and the production of oxidative stress. Memory impairment was prevented in A. paniculata-treated groups by balancing the levels of AChE and dopamine activities, which then lowered glutamate concentration, avoided oxidative stress, and improved histopathological alterations in the brain. A. paniculata alleviated HgCl2-induced memory impairment in Wistar rats by increasing the memory index, regulating neurotransmitter levels, and reducing oxidative stress.
氯化汞（HgCl2）是一种神经毒物，尽管人们为降低其在环境中的含量付出了诸多努力，但它仍然对健康构成危害。由于药用植物在治疗各种疾病及其他有毒物质方面的有效性和价格实惠，其使用已变得越来越普遍。穿心莲是一种具有收敛和解毒特性的植物，因其药用和抗氧化功效在全球范围内被广泛使用。本研究旨在探讨穿心莲水提取物对HgCl2诱导的记忆损伤、氧化应激和脑损伤的可能保护作用。将25只成年Wistar大鼠随机分为五组：对照组、HgCl2 0.5 mg/kg组、HgCl2+穿心莲250 mg/kg组、HgCl2+穿心莲500 mg/kg组或HgCl2+维生素C 200 mg/kg组。连续28天，每天通过灌胃给药一次。注射HgCl2导致记忆损伤、脑内谷氨酸浓度升高以及氧化应激的产生。穿心莲治疗组通过平衡乙酰胆碱酯酶和多巴胺活性水平预防了记忆损伤，进而降低了谷氨酸浓度，避免了氧化应激，并改善了脑内的组织病理学改变。穿心莲通过提高记忆指数、调节神经递质水平和减轻氧化应激，减轻了HgCl2诱导的Wistar大鼠记忆损伤。
