年龄对长春西汀（卡文通）和阿朴长春胺酸药代动力学的影响。
Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid.
作者信息
Miskolczi P, Vereczkey L, Szalay L, Göndöc C
机构信息
Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
出版信息
Eur J Clin Pharmacol. 1987;33(2):185-9. doi: 10.1007/BF00544565.
The pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA), were studied in the aged. Vinpocetine was eliminated with a mean half-life of 2.12 +/- 0.51 h. Total plasma clearance (CL) and distribution coefficient (delta) of the parent drug were 2.2 +/- 0.9 l.kg-1.h-1 and 6.7 +/- 3.7 l.kg-1, respectively. The CL and delta of vinpocetine differed significantly from young subjects but the elimination half-life was not altered. Significant changes in the elimination half-life and plasma clearance of AVA were found, perhaps because of the physiological decrease in renal function.
研究了长春西汀及其主要代谢产物阿朴长春胺酸（AVA）在老年人中的药代动力学。长春西汀的消除半衰期平均为2.12±0.51小时。母体药物的总血浆清除率（CL）和分布系数（δ）分别为2.2±0.9升·千克⁻¹·小时⁻¹和6.7±3.7升·千克⁻¹。长春西汀的CL和δ与年轻受试者有显著差异，但消除半衰期未改变。发现AVA的消除半衰期和血浆清除率有显著变化，这可能是由于肾功能的生理性下降所致。
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