性腺切除术对游泳应激诱导小鼠产生的抗伤害感受的影响。

The effect of gonadectomy on antinociception induced in mice by swim stress.

作者信息

Wong C L

机构信息

Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T.

出版信息

Eur J Pharmacol. 1987 Oct 6;142(1):159-61. doi: 10.1016/0014-2999(87)90668-6.

DOI:10.1016/0014-2999(87)90668-6

PMID:3691634

Abstract

A 30 s swim in water at 30 degrees C reduced the number of abdominal constrictions produced in mice by i.p. acetic acid. Naloxone antagonised this stress-induced antinociception in the female but not in the male. Orchidectomy altered neither the antinociception nor its insensitivity to naloxone antagonism. However, oophorectomy completely abolished the antinociception induced by the swim. These results suggest a sex difference in the involvement of the endogenous opioid system in swim stress-induced antinociception in mice.

摘要

在30摄氏度的水中游泳30秒可减少腹腔注射乙酸所致小鼠的腹部收缩次数。纳洛酮可拮抗雌性小鼠这种应激诱导的抗伤害感受，但对雄性小鼠无效。去势既不改变抗伤害感受，也不改变其对纳洛酮拮抗作用的不敏感性。然而，卵巢切除术完全消除了游泳诱导的抗伤害感受。这些结果表明，内源性阿片系统参与小鼠游泳应激诱导的抗伤害感受存在性别差异。