School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
School of Life Science and Engineering, Yibin Institute of Southwest Jiaotong University, Yibin 644000, China.
J Asian Nat Prod Res. 2023 Oct;25(10):1012-1020. doi: 10.1080/10286020.2023.2188203. Epub 2023 Mar 14.
Seventeen compounds were isolated and identified from the ethyl acetate part of Maxim., including one new compound 18-acetyloxyneocryptotanshinone () and 16 known compounds (). Their structures were elucidated by extensive spectroscopy. The absolute configuration of was confirmed by electronic circular dichroism (ECD). All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, of which and exhibited the most significant inhibitory effect, with IC of 17.29 and 10.27 M, respectively.
从丹参的乙酸乙酯部分分离鉴定了 17 种化合物，包括 1 个新化合物 18-乙酰氧基新丹参酮（）和 16 个已知化合物（）。通过广泛的光谱学方法阐明了它们的结构。通过电子圆二色性（ECD）确定了的绝对构型。所有化合物均评估了对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）产生的抑制作用，其中和表现出最显著的抑制作用，IC 分别为 17.29 和 10.27 μM。
